Negative Postprandial Effect on Endothelium After a Not-healthy Meal in Type 2 Diabetes as Affected by Training
NCT ID: NCT01991769
Last Updated: 2016-06-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2012-02-29
2013-11-30
Brief Summary
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Both healthy people and type 2 diabetes subjects will during three days either carry out two different sessions of exercise training or not before ingesting an unhealthy meal high in saturated fat and fast carbohydrates. The two different exercise training modes used are high intensity interval training (HIIT) and moderate intensity training (MIT) Hypothesis: Exercise training in advance of an unhealthy meal will improve endothelial- and cardiac function in healthy and type 2 diabetes individuals. HIIT will reduce the negative postprandial effects on the endothelium more than MIT.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
SINGLE
Study Groups
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exercise diabetes type 2
4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal.
47 min moderate intensity training
exercise healthy volunteers
control; no exercise training
exercise healthy volunteers
4x4 min interval training, 47 min moderate intensity training, or no exercise preceding an 'unhealthy' meal.
47 min moderate intensity training
exercise healthy volunteers
control; no exercise training
Interventions
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47 min moderate intensity training
exercise healthy volunteers
control; no exercise training
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* unstable angina
* myocardial infarction
* overt cardiovascular disease.
* severe valvular disease.
* overt lung disease.
* orthopedical- /neurological restrictions
* severe disease related to diabetes type 2 (neuropathy, micro-or macroalbuminuria, retinopathy)
* body mass index \>35
* severe eating disorders.
* personality disturbances.
* planned surgery during the project period.
* patients who achieve greater than the current exercise guidelines for type 2 diabetes (210 min/week) before the start of the study.
* uncontrolled hypertension
* kidney failure
* cardiomyopathy
* smoking
* patients who probably not will be able to complete the study
* alcohol or drug abuse
40 Years
65 Years
ALL
No
Sponsors
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St. Olavs Hospital
OTHER
Norwegian University of Science and Technology
OTHER
Responsible Party
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Principal Investigators
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Charlotte B Ingul, PhD
Role: STUDY_DIRECTOR
Norwegian University of Science and Technology
Locations
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Forskningsposten, St Olavs Hospital
Trondheim, , Norway
ISB
Trondheim, , Norway
Countries
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References
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Hollekim-Strand SM, Malmo V, Follestad T, Wisloff U, Ingul CB. Fast food increases postprandial cardiac workload in type 2 diabetes independent of pre-exercise: A pilot study. Nutr J. 2015 Aug 14;14:79. doi: 10.1186/s12937-015-0069-1.
Other Identifiers
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2011/1801
Identifier Type: -
Identifier Source: org_study_id
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