Endothelial Dysfunction Induced by Postprandial Lipemia

NCT ID: NCT00660491

Last Updated: 2012-01-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-31

Study Completion Date

2008-10-31

Brief Summary

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Postprandial lipemia and exercise oppose each other in terms of cardiovascular risk, however the mechanism of their interaction is not well understood.

Therefore we want to study vascular function, as assessed by brachial artery (BA) flow mediated dilation (FMD), in healthy men before and after a high fat meal (HFM) preceded (16-18 hrs) by rest, a single bout of continuous moderate intensity exercise (CME), and high intensity interval exercise (HIIE).

Detailed Description

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Conditions

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Healthy Subjects

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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1

Control

Group Type NO_INTERVENTION

No interventions assigned to this group

2

moderate exercise training group

Group Type NO_INTERVENTION

No interventions assigned to this group

3

high intensity exercise group

Group Type EXPERIMENTAL

exercise training

Intervention Type OTHER

moderate intensity exercise group, and high intensity exercise group

Interventions

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exercise training

moderate intensity exercise group, and high intensity exercise group

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* male, 20-40years, BMI between 25 and 30, resident in Trondheim.

Exclusion Criteria

* unstable angina, CHD, heart failure,
Minimum Eligible Age

20 Years

Maximum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Norwegian University of Science and Technology

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ulrik Wisloff, Professor

Role: STUDY_CHAIR

National Taiwan Normal University

Locations

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NTNU

Trondheim, , Norway

Site Status

Countries

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Norway

References

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Tyldum GA, Schjerve IE, Tjonna AE, Kirkeby-Garstad I, Stolen TO, Richardson RS, Wisloff U. Endothelial dysfunction induced by post-prandial lipemia: complete protection afforded by high-intensity aerobic interval exercise. J Am Coll Cardiol. 2009 Jan 13;53(2):200-6. doi: 10.1016/j.jacc.2008.09.033.

Reference Type RESULT
PMID: 19130989 (View on PubMed)

Other Identifiers

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Exercise, Food and Endothelium

Identifier Type: -

Identifier Source: org_study_id

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