Hemodynamics After Resistance Training

NCT ID: NCT07022340

Last Updated: 2025-07-11

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-06-06
• Study Completion Date: 2026-03-31

Brief Summary

Women's blood vessel health gets worse after menopause, or "the change of life". Some women exercise less during menopause. Exercise can improve blood vessel health. The investigators want to know if resistance exercise, like lifting weights, can improve blood vessel health in women who are just starting menopause. The investigators also want to know if lifting weights can improve mood, sleep, and quality of life in women going through menopause. The investigators will have two groups of women for this study. One group will lift weights (do resistance exercise) twice per week, and the other group will get emails with information about menopause. The investigators will measure blood vessel health, sleep, mood, and menopause symptoms at the start and the end of this study and compare women who did and did not exercise.

Detailed Description

Perimenopause is an important time when heart disease risk increases. Perimenopause is also related to worse health-related quality of life, sleep disruptions, and mood. Poor sleep and mood are both related to cardiovascular disease risk. Resistance exercise is effective at reducing cardiovascular disease risk in premenopausal women, and also improves mood, menopausal symptoms, and sleep quality in post-menopausal women. Resistance exercise does not consistently improve vascular function, such as arterial stiffness and blood vessel reactivity, in post-menopausal women. This study aims to investigate the effect of resistance training intervention on vascular function in perimenopausal women. This study will also determine if resistance training improves other novel cardiovascular disease risk factors that tend to worsen in perimenopause, such as sleep quality, mood, and menopause-specific quality of life.

The investigators will conduct a randomized controlled trial in perimenopausal females. Participants will complete baseline vascular function and exercise testing at baseline. Blood and urine will be collected. Participants will also complete surveys about their sleep, mood, and menopause-specific quality of life. Participants will be randomized to resistance training or control group. Those randomized to resistance training will complete two sessions per week for 16 weeks. The control group will receive a weekly health education email. Following the 16-week intervention or control, participants will complete post-intervention vascular function and exercise testing, and the same surveys as at baseline. Comparisons will be made between the exercise and control groups.

Conditions

Perimenopause

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Resistance Training Intervention

Participants randomized to resistance training will complete two sessions/week for 16 weeks.

Group Type: EXPERIMENTAL

Resistance Training Intervention

Intervention Type: BEHAVIORAL

Participants will complete a brief aerobic warm-up and dynamic stretching prior to each strength training session. Participants will complete 9 exercises for all major muscle groups. Strength testing at the baseline study visit will be used to determine initial load. Participants will complete 1 set of moderate-intensity loads (\~50% maximum and \~12 repetitions) in week 1, 2 sets in week 2, and 3 sets in week 3. By week 4, participants will be completing 3 sets at 60% of maximum. Weight loads will be progressively increased so volitional fatigue is reached by 8-12 repetitions/set.

Health Education Intervention

Participants randomized to the health education control group will receive weekly emails with general menopause information. They will be instructed to maintain current lifestyle habits, including exercise habits while enrolled in this study. They will be provided with a personalized resistance training program, equipment orientation/training session, and a counseling phone call with an exercise physiologist following study completion, or they can re-enroll in the resistance training intervention after completing the control portion of the study.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Resistance Training Intervention

Participants will complete a brief aerobic warm-up and dynamic stretching prior to each strength training session. Participants will complete 9 exercises for all major muscle groups. Strength testing at the baseline study visit will be used to determine initial load. Participants will complete 1 set of moderate-intensity loads (\~50% maximum and \~12 repetitions) in week 1, 2 sets in week 2, and 3 sets in week 3. By week 4, participants will be completing 3 sets at 60% of maximum. Weight loads will be progressively increased so volitional fatigue is reached by 8-12 repetitions/set.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Are between 40-60 years old
• Have had menstrual irregularities in the last 12 months
• Do not currently complete more than two 30-min sessions of structured exercise per week and do not do any resistance training exercise;
• Are not currently pregnant
• Do not smoke or vape nicotine or marijuana
• Have not had an oophorectomy, hysterectomy, or surgical menopause
• Are not currently taking hormone replacement therapy
• Have not taken hormone replacement therapy in the last 6 months
• Are not taking steroidal medication or medication to treat diabetes, cholesterol, or high blood pressure
• Are able to exercise - your doctor has not told you that you cannot exercise
• Can attend a morning study visit at the University of Michigan's School of Kinesiology Building
• Are willing to avoid food 2 hours prior to the morning study visit
• Are willing to avoid strenuous exercise, caffeine, and alcohol, 8 hours prior to the morning study visit
• Are willing to participate in an exercise training program or health education program for 16 weeks

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

University of Michigan

OTHER

Sponsor Role: lead

Responsible Party

Marnie McLean

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Marnie K. McLean, M.S.

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

University of Michigan School of Kinesiology

Ann Arbor, Michigan, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Marnie K. McLean, M.S.

Role: CONTACT

mcmarnie@umich.edu

734-615-1711

Abbi D. Lane, Ph.D.

Role: CONTACT

abbilane@umich.edu

734-647-3843

Facility Contacts

Marnie K. McLean, M.S.

Role: primary

mcmarnie@umich.edu

734-615-1711

Abbi D. Lane, Ph.D.

Role: backup

abbilane@umich.edu

734-647-3843

Other Identifiers

HUM00264586

Identifier Type: -

Identifier Source: org_study_id