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Resistance Training and Cardiometabolic Risk

NCT ID: NCT06054594

Last Updated: 2023-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

51 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-01-31

Study Completion Date

2011-06-09

Brief Summary

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Little is known on the effects of resistance training (RT) alone in individuals with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). The present study aimed to examine the impact of RT on body composition, physical performance, lipid-lipoprotein profile, inflammation, and glucose-insulin homeostasis in 51 sedentary, postmenopausal women categorized as MHO vs MUHO, according to the Karelis and Rabasa- Lhoret classification or a single-phenotype adiposopathy approach (the plasma adiponectin (A)/leptin (L) ratio). Participants followed a 4-month weekly RT program of 3 non-consecutive days of 6 exercises of major muscle groups (3 sets of 10 repetitions at 80% 1-RM).

Detailed Description

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Several studies have examined MHO individuals' responses to weight loss interventions. Caloric restriction decreases body weight and body fat, notably visceral fat accumulation, of both MHO and MUHO pre- and postmenopausal women, although changes in MUHO women are usually more important. In addition, while insulin sensitivity of MUHO women increases after a 12-week diet, it is significantly worsened in postmenopausal MHO women. In this regard, previous works have shown discordant data of interventions including physical activity on the cardiometabolic risk and more particularly, insulin sensitivity. Indeed, diet or aerobic training alone or combined aerobic and resistance training (RT), in men and postmenopausal women yielded promising results as insulin sensitivity increased in both MUHO and MHO participants, with greater changes in the MUHO groups. However, the heterogeneity of the population (analysis without considering sex differences) as well as the type and duration (3 to 6 months) of different interventions make it difficult to generalize these results. As an example, insulin sensitivity was improved in MUHO men and women, while it remained unchanged in MHO participants after a 9-month intervention combining diet and exercise. Moreover, a 14-week community-based aerobic exercise program increased participants' cardiorespiratory fitness and reduced the number of metabolic syndrome components of MHO men and women. However, to the best of our knowledge, no study has compared yet the impact of a RT program on MUHO and MHO individuals.

Conditions

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Metabolic Syndrome

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Metabolically healthy obesity (MHO)

Healthy/normal metabolic profile

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

After baseline testing, participants followed a progressive resistance training program 3 times a week for 4 months.

Metabolically unhealthy obesity (MUHO)

Abnormal metabolic profile

Group Type EXPERIMENTAL

Resistance exercise

Intervention Type OTHER

After baseline testing, participants followed a progressive resistance training program 3 times a week for 4 months.

Interventions

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Resistance exercise

After baseline testing, participants followed a progressive resistance training program 3 times a week for 4 months.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* cessation of menstruation for more than 1 year and a follicle-stimulating hormone level ≥ 30 IU/L
* sedentary for at least 3 months (\< 2 h/week of structured exercise)
* non-smokers
* free of known inflammatory diseases
* no use of hormone replacement therapy
* body mass index ≥ 30 kg/m2
* low to moderate alcohol consumption (\< 2 drinks/day)

Exclusion Criteria

* history of cardiovascular disease
* type 2 diabetes
* orthopedic limitations.
Minimum Eligible Age

50 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Université du Québec a Montréal

OTHER

Sponsor Role lead

Responsible Party

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Antony Karelis

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Antony Karelis, PhD

Role: PRINCIPAL_INVESTIGATOR

Université du Québec a Montréal

Other Identifiers

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UQAM-SAP

Identifier Type: -

Identifier Source: org_study_id