The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia

NCT ID: NCT03856606

Last Updated: 2019-02-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-02-20

Study Completion Date

2018-07-08

Brief Summary

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The purpose of this study is to investigate the effect of interrupting prolong sedentary behavior with interval exercise on postprandial metabolism following a high fat glucose tolerance test.

Detailed Description

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All subjects complete two trials in a randomized crossover design, with each trial occurring over 4 days with a minimum of seven days between trials. The first two days of each trial serve as a control period allowing for familiarization and the control of physical activity and calorie consumption prior to the intervention. Following each control period, subjects then perform one of the interventions on Day 3. The interventions consist of either eight-hours of prolonged sitting, or eight hours of sitting interrupted every hour by five sprints lasting 4 seconds each using the interval exercise. On day 4, all subjects will undergo a high fat glucose tolerance test to determine the body's ability to clear triglycerides from the blood as well as insulin/glucose response and substrate oxidation. Blood samples will be assayed for the previously mentioned substances and postprandial gas collection will be analyzed via indirect calorimetry.

Conditions

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Metabolic Syndrome X Atherosclerosis Insulin Resistance Hyperinsulinism Glucose Metabolism Disorders Metabolic Disease Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Cardiovascular Diseases

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Prolonged sitting without exercise

Subjects will be asked to undergo prolonged sitting (\~14 hours) of 1 day and will not be asked to perform interval exercise.

Group Type EXPERIMENTAL

Prolonged sitting without exercise

Intervention Type BEHAVIORAL

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial. Day 4 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Prolonged sitting with interval exercise

Subjects will be asked to undergo prolonged sitting (\~14 hours) of 1 day and will be asked to perform interval exercise every hour on the hour.

Group Type EXPERIMENTAL

Prolonged sitting with interval exercise

Intervention Type BEHAVIORAL

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo a prolonged sit which with will be broken up every hour on the hour by a small bout of interval exercise. Day 4 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Interventions

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Prolonged sitting without exercise

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial. Day 4 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Intervention Type BEHAVIORAL

Prolonged sitting with interval exercise

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo a prolonged sit which with will be broken up every hour on the hour by a small bout of interval exercise. Day 4 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

\-

Exclusion Criteria

* cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
* respiratory problems
* musculoskeletal problems that prevent prolonged sitting or exercise
* susceptibility to fainting
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Texas at Austin

OTHER

Sponsor Role lead

Responsible Party

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Edward F. Coyle

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Edward F Coyle, Ph.D.

Role: STUDY_DIRECTOR

University of Texas at Austin

Locations

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University of Texas at Austin Human Performance Laboratory

Austin, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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2017-11-0141

Identifier Type: -

Identifier Source: org_study_id

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