The Effects of Altering Physical Activity on Cardiometabolic Health

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-03-31

Study Completion Date

2014-10-31

Brief Summary

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The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular health. Specifically, the investigators wish to examine in healthy, lean physically active individuals (obtaining greater than 10,000 steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter blood flow following a meal a marker of vascular health. Furthermore, the investigators wish to examine if a one day return to physical activity (obtaining \>10,000 steps/day) can restore the detrimental effects on blood flow following a meal.

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Detailed Description

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Herein, we tested the hypothesis that an acute reduction in daily activity (from \>10,000 to \<5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and if a 1 day return to activity improved this outcomes.

Conditions

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Insulin Resistance

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Exercise

5 days of inactivity followed by a 1 day return to physical activity

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

short period of inactivity (5 days) followed by a return to physical activity (1 day)

Interventions

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Exercise

short period of inactivity (5 days) followed by a return to physical activity (1 day)

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* BMI: less than 30 kg/m2
* Physically active: exercise greater than 60mins per week

Exclusion Criteria

* smoking
* type 2 diabetes
* Underlying conditions that limit ability to exercise safely
* Recent weight gain or loss(\> 5% of body weight in 3 months)
* Recent (\< 3 mo) changes in medication use or dose
* Pregnancy

Minimum Eligible Age

19 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes