Acute Cardiovascular and Metabolic Effects of Exercise Training in Individuals With Insulin Resistance

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

11 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2010-12-31

Brief Summary

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The overall aim of the project is to determine whether or not exercise influences cardiovascular or nervous responses to meal ingestion in individuals with insulin resistance or type 2 diabetes.

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Detailed Description

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Participants will undergo a screening procedure, including telephone screening and physical examination, as well as determination of body composition and fitness. Participants will be asked to complete 5-10 days of supervised exercise training and will undergo testing to assess cardiovascular and metabolic responses to an oral glucose tolerance test, including muscle sympathetic nerve activity, blood flow, and circulating glucose and insulin concentrations at baseline and following training. In addition, day-to-day variations in blood glucose will also be monitored. The overall aim of the project is to determine whether or not acute exercise training influences postprandial metabolic, vascular or autonomic nervous system responses in individuals with insulin resistance or T2D.

Conditions

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Insulin Resistance

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Exercise

exercise - supervised exercise (treadmill walking or cycle ergometer use)

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

daily exercise: supervised treadmill walking or cycle ergometry use

Interventions

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Exercise

daily exercise: supervised treadmill walking or cycle ergometry use

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Insulin resistant: diagnosed with pre-diabetes or fasting blood glucose \>/= 100 mg/dL
* T2D: diagnosed by primary care physician
* BMI: less than 43 kg/m2
* Age: 30-65

Exclusion Criteria

* Smoking
* Insulin use (other than once daily)
* Underlying conditions that limit ability to exercise safely
* Recent weight gain or loss (\>5% of body weight in 3 months)
* Physically active (\>30 min aerobic exercise, 2 d/wk)
* Recent (\<3 mo) changes in medication use or dose
* Uncontrolled T2D (HbA1c\>10%)
* Advanced retinopathy or neuropathy
* Pregnancy

Minimum Eligible Age

30 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No