Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

41 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-01-01

Study Completion Date

2012-01-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study was to examine the pathophysiology of insulin resistance and the relation to the metabolic syndrome in humans.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effect of Exercise on Metabolic Health

NCT02001142

Obesity

COMPLETED NA

The Effects of Altering Physical Activity on Cardiometabolic Health

NCT01879059

Insulin Resistance

COMPLETED NA

Acute Cardiovascular and Metabolic Effects of Exercise Training in Individuals With Insulin Resistance

NCT00954109

Insulin Resistance

COMPLETED NA

Aging and Cellular Mechanism for Insulin Action After Exercise Training

NCT00018239

Diabetes Mellitus

COMPLETED NA

Muscle Lipid and Insulin Resistance in the Elderly

NCT00765505

Obesity

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

In this study insulin resistant (IR), young offspring of parents with type 2 diabetes (18-46 years) and healthy, lean elderly individuals (65-90 years) underwent 1H/13C MRS measurements of liver and muscle lipid and glycogen content before and after a high carbohydrate meal challenge. Hepatic de novo lipogenesis was determined as the incorporation of deuterium, from deuterium labeled water (2H2O), into plasma triglycerides 5. These metabolic studies were performed in 2 sets: Study Part 1: Resting, Study Part 2: After 1 bout of 45 minutes exercise.

The study has been completed and published as two papers: August 16, 2011 and July 24, 2012.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Insulin Resistance

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Exercise Training

Participants engaged in a single bout of elliptical exercise for 45 minutes (3 times 15 minutes spaced by 5 minutes rest) at baseline. Subjects will be studied before and after this one bout to measure hepatic de novo lipogenesis. Hepatic de novo lipogenesis will be compared pre and post to examine whether acutely improving muscle glucose uptake will decrease hepatic de novo lipogenesis as the glucose is taken up by muscle and not directed to the liver.

Group Type EXPERIMENTAL

one bout of 45 minutes exercise

Intervention Type OTHER

45 minutes of exercise on an elliptical exercise machine

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

one bout of 45 minutes exercise

45 minutes of exercise on an elliptical exercise machine

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Body Mass Index \< 29 kg/m2
* No regular exercise routine
* Non-smokers
* Absence of systemic and organ disease.

Exclusion Criteria

* Hematocrit \< 35 vol%
* History of claustrophobia
* Ferromagnetic implants
* Regular exercise regimen
* Not weight stable
* Any significant hematological, neurological, musculoskeletal or endocrine disease (including diabetes mellitus)
* Any significant cardiovascular condition, including confirmed CAD and prior cardiovascular events
* Taking coumadin as anticoagulant therapy.

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes