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Exercise Dose Response for Improving Insulin Sensitivity

NCT ID: NCT01452035

Last Updated: 2016-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

13 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-01-31

Study Completion Date

2015-12-31

Brief Summary

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Many of the beneficial metabolic effects of endurance exercise training are not due to adaptations to weeks, months, or even years of training, but rather much is due to the response to the most recent exercise session(s). Therefore, the investigators contend that lifestyle interventions for obese individuals should be tailored to optimize the metabolic effects of the most recent exercise session(s). But the "dose" of exercise necessary to evoke these beneficial responses is not known, and the mechanisms responsible for these improvements are poorly understood. The findings from these studies will: 1) establish the minimum "dose" of a single exercise session necessary to improve insulin sensitivity the next day in obese adults, 2) characterize the underlying metabolic factors responsible for the improvement in insulin sensitivity, and 3) assess the cumulative metabolic adaptations that occur over days, weeks, and months of a low-intensity/low-volume lifestyle exercise program. Findings from these studies will provide valuable information for the development of lifestyle programs aimed at maximizing the key metabolic health benefits of each exercise session in obese patients.

Detailed Description

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Conditions

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Obesity

Keywords

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insulin sensitivity fatty acid metabolism exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Exercise

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

single session of exercise

Sedentary Control

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise

single session of exercise

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Body Mass Index \[BMI\] = 30-45 kg/m2, weight stable (± 5 lbs in the past month), fasting blood glucose concentration must be \<125 mg/dl.

Exclusion Criteria

* pregnancy, evidence of cardiovascular or metabolic disease, taking medications know to influence metabolism.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

University of Michigan

OTHER

Sponsor Role lead

Responsible Party

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Jeffrey F Horowitz

Associate Professor, Movement Science, School of Kinesiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jeffrey F Horowitz, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Michigan

Locations

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Michigan Clincal Research Unit

Ann Arbor, Michigan, United States

Site Status

Countries

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United States

Other Identifiers

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R01DK077966

Identifier Type: NIH

Identifier Source: secondary_id

View Link

R01 DK077966 - MX

Identifier Type: -

Identifier Source: org_study_id