Effects of Sedentary Behaviour on Metabolic Parameters

NCT ID: NCT02088827

Last Updated: 2022-11-02

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-01-01
• Study Completion Date: 2021-09-01

Brief Summary

The rates of sedentary activity are increasing. Studies have shown that time spent on doing sedentary activities is an independent risk factor for cardiovascular disease. Prior studies have shown that interrupting inactivity improved the body's handling of blood glucose and gene expression. The investigators plan to explore this further by examining the effects of interrupting 4 hours of inactivity with 2 minutes of moderate intensity exercise every 20 minutes on the following metabolic parameters: blood pressure, cortisol, C-Reactive Protein, glucose and insulin levels.

Detailed Description

There is a current trend towards increasing time spent in sedentary behaviour. More jobs are being automated, and more time is spent in front of a computer, playing video games and watching television.Current studies suggest that sedentary behaviour is an independent risk factor for cardiovascular disease. Increasing time spent in sedentary behaviour has been linked to all-cause mortality, markers of cardiovascular disease and metabolic syndrome. However, the data is mainly from cross-sectional studies and based on self-recall, limiting the ability to draw definitive conclusions.

Current exercise guidelines recommend at least 150 minutes of moderate to vigorous intensity exercise per week. It may be difficult for some elderly people to meet these guidelines. Older adults with diabetes are already at a higher risk fo conditions that are affected by sedentary behaviour and may stand to benefit the most from intervention.

This study proposes to study the effects of breaking up sedentary activity with moderate intensity exercise on multiple metabolic parameters in older adults with diabetes.

Conditions

Sedentary Lifestyle; Type 2 Diabetes

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Activity

During a 4 hour Meal Test subjects will cycle for 2 minutes every 20 minutes

Group Type: OTHER

Activity

Intervention Type: OTHER

Subjects will spend 4 hours of inactivity (lying on a bed) broken up by 2 minutes of moderate intensity biking (on a stationary bike) every 20 minutes.

Inactivity

During a 4 hour Meal Test study subjects will remain inactive (remain lying on a bed)

Group Type: OTHER

Inactivity

Intervention Type: OTHER

Subjects will remain inactive (lying on a bed) for 4 hours.

Interventions

Inactivity

Subjects will remain inactive (lying on a bed) for 4 hours.

Intervention Type: OTHER

Activity

Subjects will spend 4 hours of inactivity (lying on a bed) broken up by 2 minutes of moderate intensity biking (on a stationary bike) every 20 minutes.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 65 years of age or older
• type 2 diabetes managed with diet or oral hypoglycemic agents

Exclusion Criteria

• using insulin to manage diabetes
• baseline of pre-session blood glucose reading equal to or greater than 10 mmol/L
• any medical condition that would limit the ability to perform activity portion of the study
• people not comfortable exercising on a stationary bicycle
• subject answers yes to one of more of the questions in the Physical Activity Readiness Questionnaire

• Minimum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of British Columbia

OTHER

Sponsor Role: lead

Responsible Party

Kenneth Madden

Head, VGH Division of Geriatric Medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Kenneth M Madden, MSc, MD

Role: PRINCIPAL_INVESTIGATOR

University of British Columbia

Locations

Gerontology Research Lab

Vancouver, British Columbia, Canada

Countries

Canada

Other Identifiers

H13-01886

Identifier Type: -

Identifier Source: org_study_id