Investigation of the Effects of Sedentary Behaviour and Moderate Exercise on Glucose Tolerance and Insulin Sensitivity

NCT ID: NCT03827239

Last Updated: 2021-01-29

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: NA
• Total Enrollment: 6 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-01-17
• Study Completion Date: 2019-12-31

Brief Summary

Individuals with pre-diabetes or diabetes would benefit from low impact methods that would improve their insulin sensitivity and aid in maintaining glucose homeostasis. Physical activity helps the body decrease its insulin resistance and burn excess sugar. Many diabetics also suffer from obesity and specific forms or durations of physical exercise may not be viable options for these individuals. Determining whether short bursts of moderate exercise improve blood glucose levels in healthy humans may identify a further method for diabetics to improve their glucose homeostasis.

The aim of this study is to determine the most effective moderate exercise that can be completed in 3 minutes and its effectiveness on improving glucose handling, in response to a single day of standardized high-fat and high-carbohydrate feeding in comparison to periods of prolonged sitting.

Conditions

Sedentary Lifestyle; Insulin Sensitivity; Glucose Metabolism

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Control

No intervention. Study participants will be seated during the entire sedentary 3-hour time period and wheeled to phlebotomy (and exercise) stations when required. During the sedentary period, participants will eat the food according to the study protocol and be seated at desks and allowed to read and use computers.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Intervention

Will disrupt their sedentary time with 3 minute exercise sessions every 30 minutes

Group Type: EXPERIMENTAL

Activity/Moderate Exercise

Intervention Type: OTHER

3-hour sedentary period with 3 minute activity breaks of moderate exercise every 30 minutes

Interventions

Activity/Moderate Exercise

3-hour sedentary period with 3 minute activity breaks of moderate exercise every 30 minutes

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• healthy
• BMI between 18-30 kg/m²
• non-smoker

Exclusion Criteria

• pregnant
• diabetes
• kidney disease
• liver disease
• cardiovascular disease
• cancer

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Prince Edward Island

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Magdalena Mahlstedt, PhD

Role: STUDY_DIRECTOR

University of Prince Edward Island

Locations

University of Prince Edward Island

Charlottetown, Prince Edward Island, Canada

Countries

Canada

Other Identifiers

6007895

Identifier Type: -

Identifier Source: org_study_id