Breaks in Sedentary Time and Glucose Regulation in Women
NCT ID: NCT02135172
Last Updated: 2014-12-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
22 participants
INTERVENTIONAL
2013-10-31
2014-11-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
PREVENTION
NONE
Study Groups
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Sitting
During the sitting treatment condition, walking and standing will be restricted. Participants will be in a designated room with access to a computer, books/magazines throughout the day. Participants will have a cannula fitted and the first of the half-hourly blood samples will be taken (time point: -1hr). Participants will then be asked to sit quietly for 60 minutes to achieve a steady state. Following this, participants will have another blood sample taken and then be provided with a standardised mixed meal breakfast (09:00am) (time point: 0h). Blood sampling will continue at 30 minutes intervals for 3 hours following breakfast. A second, lunch meal (12:00pm), will be then be consumed over 15 minutes. Blood sampling will then continue at 30 minute intervals for 3 hours following lunch.
Sitting
Standing
This is the same as the sitting condition, but participants will be asked to break their sitting time by standing close to their chair for 5 minutes, after 15 and 45 minutes of each hour following breakfast. The standing protocol will be repeated after lunch. Individuals will be asked to stand in the same position with no further instructions provided. In total, individuals will accumulate 12 bouts (60 minutes) of standing throughout the test period.
Standing
Walking
This is identical to the standing condition, but the breaks in sitting time will be punctuated with 5 minute bouts of light-intensity treadmill walking (equivalent to around 4.0km•h-1) rather than standing. In total, individuals will accumulate 12 bouts (60 minutes) of light-intensity activity throughout the test period. The light-intensity walking activity undertaken here replicates the low-grade ambulatory activity associated with everyday life.
Walking
Interventions
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Sitting
Standing
Walking
Eligibility Criteria
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Inclusion Criteria
* Overweight or obese (BMI\>25kg/m2)
* Post menopausal
* Previous diagnosis of impaired glucose tolerance
Exclusion Criteria
* Physical condition which limits full participation in the study
* Active psychotic illness or other significant illness which, in the view of the investigators, would prevent full participation
* Inability to communicate in spoken English
* Steroid use
* Known Type 2 Diabetes
* Pregnancy
* Male
* Currently taking hormone replacement medication.
50 Years
74 Years
FEMALE
No
Sponsors
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National Institute for Health Research, United Kingdom
OTHER_GOV
National Health Service, United Kingdom
OTHER_GOV
University of Leicester
OTHER
Responsible Party
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Principal Investigators
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Melanie J Davies, MD
Role: PRINCIPAL_INVESTIGATOR
University of Leicester
Locations
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Leicester Diabetes Centre, Leicester General Hospital
Leicester, Leicestershire, United Kingdom
Countries
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References
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Henson J, Davies MJ, Bodicoat DH, Edwardson CL, Gill JM, Stensel DJ, Tolfrey K, Dunstan DW, Khunti K, Yates T. Breaking Up Prolonged Sitting With Standing or Walking Attenuates the Postprandial Metabolic Response in Postmenopausal Women: A Randomized Acute Study. Diabetes Care. 2016 Jan;39(1):130-8. doi: 10.2337/dc15-1240. Epub 2015 Dec 1.
Related Links
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Click here for more information about this study
Other Identifiers
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0376
Identifier Type: -
Identifier Source: org_study_id