Exercise Effects on Cardiovascular Risk Factors, Quality of Life, Muscle Function in Type 2 Diabetes and Healthy Persons

NCT ID: NCT00852982

Last Updated: 2009-03-02

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 213 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2006-04-30
• Study Completion Date: 2009-09-30

Brief Summary

A sedentary lifestyle is known to be a risk factor to developing type 2 diabetes. The aim of this study was to determine the effects of adding regular Nordic walking to daily physical activity. Effects on quality of life, cardiovascular risk factors and functions in muscle cells will be determined.

Detailed Description

Regular physical activity is known to have a beneficial effect on several factors affecting the risk of developing cardiovascular disease and type 2 diabetes. Implementing and maintaining changes of lifestyle is, however, known to be difficult. In this study we wished to investigate the effects of an exercise intervention that is feasible to most people with type 2 diabetes or at risk of developing that disease. The intervention was Nordic walking (with walking poles) for five hour per week, during four months. We chose to determine effects on health related quality of life, clinical parameters related to body weight/body composition, blood pressure, glucose metabolism, insulin resistance, blood lipids, oxygen uptake and physiological effects in skeletal muscle cells related to glucose metabolism.

On inclusion and after four months the participants were therefore subject to clinical measurements, blood samples, maximal oxygen uptake tests on an ergometer cycle and muscle biopsies at inclusion and after four months of participation. They also answered an extensive questionnaire focusing on health related quality of life.

Conditions

Type 2 Diabetes; Impaired Glucose Tolerance

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Exercise

Five hours of Nordic walking per week, during four months

Group Type: EXPERIMENTAL

Exercise

Intervention Type: BEHAVIORAL

Nordic walking, with walking poles, five hours per week during four months

Control

Control group asked not to alter lifestyle during study

Group Type: NO_INTERVENTION

Exercise

Intervention Type: BEHAVIORAL

Nordic walking, with walking poles, five hours per week during four months

Interventions

Exercise

Nordic walking, with walking poles, five hours per week during four months

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• BMI>25

Exclusion Criteria

• Physical impairment
• Symptomatic angina pectoris
• Insulin treatment

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 69 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Karolinska Institutet

OTHER

Sponsor Role: lead

Responsible Party

Dep. of molecular medicine and surgery, Karolinska Institutet

Principal Investigators

Juleen Zierath, Professor

Role: PRINCIPAL_INVESTIGATOR

Dep. of molecular medicine and surgery, Karolinska Institutet

Locations

Primary health care center

Stockholm, , Sweden

Countries

Sweden

References

Osler ME, Fritz T, Caidahl K, Krook A, Zierath JR, Wallberg-Henriksson H. Changes in gene expression in responders and nonresponders to a low-intensity walking intervention. Diabetes Care. 2015 Jun;38(6):1154-60. doi: 10.2337/dc14-2606. Epub 2015 Mar 20.

Reference Type: DERIVED

PMID: 25795414 (View on PubMed)

Fritz T, Caidahl K, Osler M, Ostenson CG, Zierath JR, Wandell P. Effects of Nordic walking on health-related quality of life in overweight individuals with type 2 diabetes mellitus, impaired or normal glucose tolerance. Diabet Med. 2011 Nov;28(11):1362-72. doi: 10.1111/j.1464-5491.2011.03348.x.

Reference Type: DERIVED

PMID: 21658122 (View on PubMed)

Other Identifiers

ALF 2006 03 25

Identifier Type: -

Identifier Source: org_study_id