Effects of Six Months of Moderate Resistance- Versus Endurance-Training on Muscle ATP Synthesis in First-Degree Relatives of Patients With Type 2 Diabetes

NCT ID: NCT01145092

Last Updated: 2010-06-16

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 16 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2006-02-28
• Study Completion Date: 2009-03-31

Brief Summary

Life style intervention including diet and exercise is the recommended strategy for prevention of type 2 diabetes mellitus (T2DM). First-degree relatives of patients with type 2 diabetes mellitus have an increased risk of insulin resistance and a lifetime risk of developing type 2 diabetes of 40%- 80%. Poor physical fitness is a strong indicator of an increased risk of developing diabetes.

Long-term endurance exercise training has been shown to increase insulin sensitivity in sedentary young and elderly individuals, first degree relatives of patients with Type 2 diabetes, glucose intolerant obese, or Type 2 diabetic humans. In type 2 diabetic patients, non-diabetic individuals with IGT and sedentary adults after exercise training of different intensity, different duration and different frequency an increase of insulin sensitivity was found.

However, despite the vast knowledge concerning beneficial effects physical activity for the prevention of T2DM (and many other chronic metabolic disorders) to date wide ranging strategies have not been realized satisfactory. Regardless of age, ethnicity, sex or health status the lack of time is the primary reason for the failure to exercise on a regular basis (or is stated as primary reason). Therefore the investigators aimed at investigating whether a controlled endurance/resistance training twice a week over 6 month might be beneficial for healthy, non obese, first degree relatives with T2DM. Therefore the investigators measure parameters associated with the prevention of T2DM like insulin sensitivity, flux through fATPase and fCK, intramyocellular and hepatocellular lipids.

Conditions

Type 2 Diabetes Mellitus; Insulin Resistance

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Interventions

exercise training, endurance training

The endurance training group exercised on a cycle ergometer (90% of power output determined at the respiratory compensation point = RCP). The duration of each training unit was increased with time. The resistance group trained on 8 weight machines where the workload gradually increased every 2-3 weeks. At week 13 an additional physical examination, OGTT and spiro-ergometry for adjusting the training were performed.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• First degree relatives of type 2 diabetic patients
• Age: 18-50 years
• BMI <30 kg/m2 (due to limited MR diameter)
• Normal routine lab tests (blood cell count, kidney, liver, pancreas, thyroid and neuromuscular function)
• Availability within the local area throughout the study
• Ability to understand and sign the consent forms

Exclusion Criteria

• Current smoking
• Present drug treatment
• Regular exercise training
• Contraindications for MRS studies: claustrophobia and metalliferous implants
• Pregnancy
• HIV or Hepatitis
• Acute disease 2 weeks previous to the examination
• Heart disease
• Hypertension (RR>140/95)
• Liver disease
• Kidney disease
• Pulmonary disease
• Thyroid disease

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Mein Hanusch-Krankenhaus

OTHER

Sponsor Role: collaborator

Karl-Landsteiner Institute for Endocrinology and Metabolism

UNKNOWN

Sponsor Role: collaborator

Medical University of Vienna

OTHER

Sponsor Role: collaborator

Lund University

OTHER

Sponsor Role: collaborator

Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy

OTHER_GOV

Sponsor Role: collaborator

Landsteiner Institut

OTHER

Sponsor Role: lead

Responsible Party

Landsteiner Institute

Principal Investigators

Michael Roden, Prof.

Role: STUDY_DIRECTOR

Institute for Clinical Diabetology, German Diabetes Center (Leibniz Center for Diabetes Research), Department of Metabolic Diseases, Heinrich-Heine University and University Clinics Düsseldorf, Germany

Locations

Landsteiner Institute

Vienna, Vienna, Austria

Countries

Austria

Other Identifiers

P15656

Identifier Type: -

Identifier Source: org_study_id