Exercise Intervention Combined With Metformin in the Treatment of Type 2 Diabetes
NCT ID: NCT05004948
Last Updated: 2021-08-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
57 participants
INTERVENTIONAL
2019-01-01
2019-10-15
Brief Summary
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Detailed Description
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Methods: A total of fifty-seven T2DM patients with a mean age of 46.2±8.3 years were randomized to three study groups; each group included nineteen patients. The first group conducted a resistance exercise program (REP, 50-60% of 1RM, for 40-50 min) combined with metformin, the second group conducted an aerobic exercise program (AEP, 50-70% maxHR, for 40-50 min) combined with metformin, and the third group received only metformin without exercise intervention (Met group). The study program was conducted thrice weekly for consecutive twelve weeks. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), and maximal oxygen uptake (VO2max) were evaluated before and after study intervention.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Resistance exercise group
This group has conducted a resistance exercise program (50-60% of 1RM, for 40-50 min) thrice weekly for consecutive twelve weeks plus metformin medication.
Exercise training
The first group conducted a resistance exercise program (REP, 50-60% of 1RM, for 40-50 min) combined with metformin, the second group conducted an aerobic exercise program (AEP, 50-70% maxHR, for 40-50 min) combined with metformin, and the third group received only metformin without exercise intervention (Met group). The study program was conducted thrice weekly for consecutive twelve weeks.
Aerobic exercise program
This group has conducted an aerobic exercise program ( 50-70% maxHR, for 40-50 min) thrice weekly for consecutive twelve weeks plus metformin medication.
Exercise training
The first group conducted a resistance exercise program (REP, 50-60% of 1RM, for 40-50 min) combined with metformin, the second group conducted an aerobic exercise program (AEP, 50-70% maxHR, for 40-50 min) combined with metformin, and the third group received only metformin without exercise intervention (Met group). The study program was conducted thrice weekly for consecutive twelve weeks.
Metformin group
This group received only metformin without any exercise intervention.
No interventions assigned to this group
Interventions
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Exercise training
The first group conducted a resistance exercise program (REP, 50-60% of 1RM, for 40-50 min) combined with metformin, the second group conducted an aerobic exercise program (AEP, 50-70% maxHR, for 40-50 min) combined with metformin, and the third group received only metformin without exercise intervention (Met group). The study program was conducted thrice weekly for consecutive twelve weeks.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Glycated hemoglobin (HbA1c) ≥8.0%
* A previous inactive lifestyle
* Not receiving insulin or diabetic medications except for metformin
* Metformin dosage of 1000-1500 mg daily.
Exclusion Criteria
* Pregnancy
* Corticosteroid medications
* Uncontrolled systemic diseases
* Any physical limits that affect exercise training
35 Years
55 Years
ALL
No
Sponsors
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Prince Sattam Bin Abdulaziz University
OTHER
Responsible Party
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Principal Investigators
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Walid Kamal Abdelbasset, PhD
Role: PRINCIPAL_INVESTIGATOR
Prince Sattam Bin Abdulaziz University
Locations
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Prince Sattam bin Abdulaziz University
Al Kharj, Riyadh Region, Saudi Arabia
Countries
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Other Identifiers
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RHPT/018/029
Identifier Type: -
Identifier Source: org_study_id
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