SIT LESS 4: How Does Reducing Sitting Time Improve Glucose and Lipid Metabolism?

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-12-15

Study Completion Date

2020-03-13

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Research has shown that replacing sitting time with low intensity physical activity (such as slowly walking and standing) has beneficial effects on metabolic health, like insulin sensitivity, comparable to improvements after sitting all day in combination with 1h streneous exercise.

The main objective of this study is to investigate the underlying mechanisms responsible for improved insulin sensitivity after 4 days of sitting less compared to sitting and exercise in healthy obese women. Our secondary objective is to investigate the effects of sitting less on cardio metabolic parameters.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

SIT LESS 2: Effect of Sitting Less on Glucose Regulation in People With Diabetes Mellitus Type 2

NCT02371239

Type 2 Diabetes

COMPLETED NA

FIT 2 SIT - Are Metabolic Responses to Sitting/Light Breaks Mediated by Fitness?

NCT02493309

Diabetes

COMPLETED NA

Low Intensity Physical Activity During Sitting on Glycemic Control and Vascular Function in Obese Individuals

NCT03419754

Obesity Metabolic Syndrome

COMPLETED NA

Effects of Physical Inactivity on Insulin Sensitivity, Appetite, Energy Balance, and Cardiovascular Responses in Humans.

NCT04172090

Sedentary Behavior

COMPLETED NA

Breaks in Sedentary Time and Glucose Regulation in Women

NCT02135172

Impaired Glucose Tolerance

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Overweight and Obesity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Sit regime

Subjects will follow the sit regime during four days. Each day consists of 14 hours sitting, 1 hour walking and 1 hour standing and 8 hours sleeping.

Group Type EXPERIMENTAL

Activity regime

Intervention Type OTHER

Activity regime of 4 days followed by a test day.

Sit less regime

Subjects will follow the sit less regime during four days. Each day will consist of 9 hours sitting, 3 hours walking, 4 hours standing and 8 hours sleeping.

Group Type EXPERIMENTAL

Activity regime

Intervention Type OTHER

Activity regime of 4 days followed by a test day.

Exercise regime

Subjects will follow the exercise regime during four days. Each day will consist of 13 hours sitting, 1 hour walking, 1 hour standing, 1 hour exercise and 8 hours sleeping. The cycle session will be at approximately 60% maximal power. Exact cycling intensity and duration will be calculated to ensure equal total energy expenditure between the sitting less and the exercise regime.

Group Type EXPERIMENTAL

Activity regime

Intervention Type OTHER

Activity regime of 4 days followed by a test day.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Activity regime

Activity regime of 4 days followed by a test day.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Signed informed consent
* Caucasian
* Postmenopausal women
* Aged 45-70 years at start of the study
* Body mass index (BMI) 25 - 35 kg/m2
* Stable dietary habits (no weight loss or gain \>5kg in the past 3 months)
* Sedentary lifestyle (not more than 2,5 hours of exercise per week in the past 3 months)

Exclusion Criteria

* Not able to complete the sitless try-out day according to the protocol
* Active diseases (cardiovascular, diabetes, liver, kidney, cancer or other)
* No use of medication interfering with investigated study parameters (as determined by responsible physician)
* Alcohol consumption of \>2 servings per day
* Smoking in the past 6 months
* Participation in another biomedical trial which may have an effect on insulin sensitivity less than one month before the start of the study (screening visit)
* Mental or physical disability which interferes with physical activity
* Subjects with contra-indications for magnetic resonance imaging (MRI)
* Reported participation in night shift work 2 weeks prior to the start of the study (screening visit) and during study participation. Night work is defined as working between midnight and 6.00 AM.

Minimum Eligible Age

45 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes