The Effect of Sitting and Moderate Exercise on Plasma Triglyceride Elevation After a Meal

NCT ID: NCT03098446

Last Updated: 2018-10-05

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-04-08
• Study Completion Date: 2017-08-11

Brief Summary

The purpose of this study is to investigate the effect of 4 days of sitting and moderate exercise on plasma triglyceride elevation after a meal.

Detailed Description

Subjects will undergo three weeks (two intervention, one washout) of testing during which they will participate in two conditions: 1) prolonged sitting (~14-hours/day) with a 1-hour bout of acute exercise at 65% of pre-intervention VO2max and 2) prolonged sitting (~14-hours/day) without an acute bout of exercise. During each intervention week, subjects will have 2 days of dietary and activity control, followed by 4 days during which prolonged sitting will occur. On the evening of the 4th day, subjects in the exercise group will perform the acute bout of exercise. On day 5, all subjects will undergo a lipid tolerance test to determine the body's ability to clear triglycerides from the blood as well as insulin/glucose response and substrate oxidation. Blood samples will be assayed for the previously mentioned substances and postprandial gas collection will be analyzed via indirect calorimetry.

Conditions

Atherosclerosis; Metabolic Syndrome

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Prolonged sitting with exercise

Subjects will be asked to undergo prolonged sitting (\~14-hours/day) for 4 days. On the evening of day 4, they will be asked to run at 65% of VO2max for 1-hour.

Group Type: EXPERIMENTAL

Prolonged sitting with exercise

Intervention Type: BEHAVIORAL

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial with the acute bout of exercise on day 4. Day 5 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Prolonged sitting without exercise

Subjects will be asked to undergo prolonged sitting (\~14-hours/day) for 4 days. Subjects will not be asked to complete the acute bout of exercise to serve as a control.

Group Type: EXPERIMENTAL

Prolonged sitting without exercise

Intervention Type: BEHAVIORAL

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial, but will not be asked to complete an acute bout of exercise on day 4. Day 5 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Interventions

Prolonged sitting with exercise

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial with the acute bout of exercise on day 4. Day 5 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Intervention Type: BEHAVIORAL

Prolonged sitting without exercise

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial, but will not be asked to complete an acute bout of exercise on day 4. Day 5 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

-

Exclusion Criteria

• cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
• respiratory problems
• musculoskeletal problems that prevent prolonged sitting or exercise
• obesity
• susceptibility to fainting

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Texas at Austin

OTHER

Sponsor Role: lead

Responsible Party

Edward F. Coyle

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of Texas at Austin Human Performance Laboratory

Austin, Texas, United States

Countries

United States

Other Identifiers

2016-12-0022

Identifier Type: -

Identifier Source: org_study_id