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Exercise Training in Obesity-prone Black and White Women

NCT ID: NCT00067873

Last Updated: 2017-11-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

231 participants

Study Classification

INTERVENTIONAL

Study Start Date

2000-12-31

Study Completion Date

2007-12-31

Brief Summary

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Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

Detailed Description

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Overweight premenopausal Black and White women are randomized to either diet-only, diet+aerobic or diet+resistance exercise training. Diet/behavior intervention, with or without the aerobic or resistance exercise training, will be provided throughout the 18 months of study. Major outcomes will include measures of perceived and physiologic difficulty of exercise (cardiac, ventilatory, electromyographic responses to standardized exercise tasks); aerobic fitness; strength fitness; and spontaneous free-living energy expenditure (all derived from doubly labeled water). The results will provide insight into the effectiveness of, and the mechanisms by which, different types of exercise training can improve physical fitness, spontaneous engagement in physical activities of daily living and, in turn, weight-loss maintenance.

Time of initial weight loss was defined as the time needed to reach the goal of 25 kg/m2 BMI. The women will then be evaluated one year after this time and the amount of weight gain will be determined.

Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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Diet only

Group Type ACTIVE_COMPARATOR

Diet

Intervention Type BEHAVIORAL

Diet plus aerobic exercise

Group Type EXPERIMENTAL

Diet

Intervention Type BEHAVIORAL

Aerobic exercise

Intervention Type BEHAVIORAL

Diet plus resistance exercise

Group Type EXPERIMENTAL

Diet

Intervention Type BEHAVIORAL

Resistance exercise

Intervention Type BEHAVIORAL

Interventions

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Diet

Intervention Type BEHAVIORAL

Aerobic exercise

Intervention Type BEHAVIORAL

Resistance exercise

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Normoglycemic
* BMI between 27-30
* Non smoker
* Premenopausal
* Physically untrained
* Family history of obesity
Minimum Eligible Age

21 Years

Maximum Eligible Age

41 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

Sponsor Role collaborator

University of Alabama at Birmingham

OTHER

Sponsor Role lead

Responsible Party

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Gary Hunter, PhD

Principle Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gary R Hunter, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Alabama at Birmingham

Locations

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University of Alabama at Birmingham

Birmingham, Alabama, United States

Site Status

Countries

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United States

References

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Hunter GR, Fisher G, Neumeier WH, Carter SJ, Plaisance EP. Exercise Training and Energy Expenditure following Weight Loss. Med Sci Sports Exerc. 2015 Sep;47(9):1950-7. doi: 10.1249/MSS.0000000000000622.

Reference Type RESULT
PMID: 25606816 (View on PubMed)

Hunter GR, Brock DW, Byrne NM, Chandler-Laney PC, Del Corral P, Gower BA. Exercise training prevents regain of visceral fat for 1 year following weight loss. Obesity (Silver Spring). 2010 Apr;18(4):690-5. doi: 10.1038/oby.2009.316. Epub 2009 Oct 8.

Reference Type RESULT
PMID: 19816413 (View on PubMed)

Bartholomew CL, Martins C, Gower B. The Role of Insulin Sensitivity in Lean Mass Changes During Weight Loss With or Without Exercise. Obesity (Silver Spring). 2025 Sep 2. doi: 10.1002/oby.70010. Online ahead of print.

Reference Type DERIVED
PMID: 40898644 (View on PubMed)

Martins C, Gower BA, Hunter GR. Changes in Trunk, but Not Limb, Lean Body Mass Contribute to Variability in Metabolic Adaptation Following Weight Loss. Obes Sci Pract. 2025 Mar 19;11(2):e70054. doi: 10.1002/osp4.70054. eCollection 2025 Apr.

Reference Type DERIVED
PMID: 40110172 (View on PubMed)

Martins C, Gower BA, Hunter GR. Association between Fat-Free Mass Loss after Diet and Exercise Interventions and Weight Regain in Women with Overweight. Med Sci Sports Exerc. 2022 Dec 1;54(12):2031-2036. doi: 10.1249/MSS.0000000000002992. Epub 2022 Jul 8.

Reference Type DERIVED
PMID: 35797356 (View on PubMed)

Martins C, Gower BA, Hill JO, Hunter GR. Metabolic adaptation is not a major barrier to weight-loss maintenance. Am J Clin Nutr. 2020 Sep 1;112(3):558-565. doi: 10.1093/ajcn/nqaa086.

Reference Type DERIVED
PMID: 32386226 (View on PubMed)

Brock DW, Tompkins CL, Fisher G, Hunter GR. Influence of resting energy expenditure on blood pressure is independent of body mass and a marker of sympathetic tone. Metabolism. 2012 Feb;61(2):237-41. doi: 10.1016/j.metabol.2011.06.019. Epub 2011 Aug 4.

Reference Type DERIVED
PMID: 21820136 (View on PubMed)

Brock DW, Chandler-Laney PC, Alvarez JA, Gower BA, Gaesser GA, Hunter GR. Perception of exercise difficulty predicts weight regain in formerly overweight women. Obesity (Silver Spring). 2010 May;18(5):982-6. doi: 10.1038/oby.2009.318. Epub 2009 Oct 8.

Reference Type DERIVED
PMID: 19816412 (View on PubMed)

Other Identifiers

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R01DK049779

Identifier Type: NIH

Identifier Source: secondary_id

View Link

BLKWHT (DK49779) (completed)

Identifier Type: -

Identifier Source: org_study_id