Effects of Physical Training on Adipose Tissue Metabolism and Insulin Sensitivity in the Menopausal Transition Phase

NCT ID: NCT02076932

Last Updated: 2016-06-01

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 43 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-04-30
• Study Completion Date: 2016-01-31

Brief Summary

The purpose of this study is to determine if physical exercise reduces the adverse changes in adipose tissue metabolism and insulin sensitivity that occurs in women during the menopausal transition.

Conditions

Menopause; Insulin Resistance; Body Composition, Beneficial

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Premenopausal women

The premenopausal women will be attending Spinning classes.

Group Type: ACTIVE_COMPARATOR

Spinning

Intervention Type: BEHAVIORAL

After the baseline studies, the women will perform Spinning three times a week. Two of the sessions are performed on our location by trained instructors and the third training is self-training in a local fitness center where we provide free membership. All trainings are heart rate monitored.

Postmenopausal Women

The postmenopausal women will be attending Spinning classes.

Group Type: EXPERIMENTAL

Spinning

Intervention Type: BEHAVIORAL

After the baseline studies, the women will perform Spinning three times a week. Two of the sessions are performed on our location by trained instructors and the third training is self-training in a local fitness center where we provide free membership. All trainings are heart rate monitored.

Interventions

Spinning

After the baseline studies, the women will perform Spinning three times a week. Two of the sessions are performed on our location by trained instructors and the third training is self-training in a local fitness center where we provide free membership. All trainings are heart rate monitored.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Premenopausal OR Postmenopausal (45-57 years)
• No chronical Diseases
• BMI > 18,5 and < 30
• Sedentary (no regular physical activity the last 2 years)
• Either regular bleeding (premenopausal) OR no menstruation for at least 2 years (postmenopausal)
• Plasma measurements:

Premenopausal: estradiol > 0.20nmol/l, Follicle Stimulating Hormone < 22 IU/l and progesterone > 2.5 nmol/l Postmenopausal: estradiol < 0.20nmol/l, Follicle Stimulating Hormone > 22 IU/l and progesterone from 0.3-2.5 nmol/l

Exclusion Criteria

• Smoking
• Excessive alcohol intake
• Regular medication including hormone replacement treatment

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 57 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Rigshospitalet, Denmark

OTHER

Sponsor Role: collaborator

Glostrup University Hospital, Copenhagen

OTHER

Sponsor Role: collaborator

University of Copenhagen

OTHER

Sponsor Role: lead

Responsible Party

Bente Merete Stallknecht

Professor, MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Ylva Hellsten, Proff.

Role: PRINCIPAL_INVESTIGATOR

University of Copenhagen

Bente M Stallknecht, Proff. MD

Role: PRINCIPAL_INVESTIGATOR

University of Copenhagen

Locations

Department og Biomedical Sciences

Copenhagen N, , Denmark

Countries

Denmark

Other Identifiers

CWS menopause, adipose tissue

Identifier Type: -

Identifier Source: org_study_id