The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes
NCT ID: NCT01344928
Last Updated: 2011-04-29
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
INTERVENTIONAL
Brief Summary
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Detailed Description
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Conditions
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Study Groups
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HIT training
HIT exercise intervention
Aerobic exercise training
Aerobic exercise intervention
Interventions
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HIT exercise intervention
Aerobic exercise intervention
Eligibility Criteria
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Inclusion Criteria
1. Age 40-55
2. BMI 18.5-30
3. Fasting plasma glucose less than 6.1 mmol/l
4. Normal glucose tolerance test (OGTT)
The type 2 diabetic patients:
1. Age-, sex-, and BMI-matched with the study subjects in the phase 1
2. In a good treatment balance
3. Glycated haemoglobin (HbA1c) less than 7.5 mmol/l
4. Two hours glucose value in oral glucose tolerance test (OGTT) less than 10.0 mmol/l
Exclusion Criteria
1. Blood pressure \> 140/90 mmHg
2. Any chronic disease
3. Any chronic medical defect or injury which hinder/interfere everyday life
4. History of anorexia nervosa or bulimia
5. History of rest or exercise-induced asthma
6. Previous use of anabolic steroids, additives or any other substrates
7. Smoking of tobacco, taking of snuffs, or use of narcotics.
8. Significant use of alcohol
9. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
10. Presence of any ferromagnetic objects that would make MR imaging contraindicated
11. Current or history of regular and systematic exercise training
12. VO2max \>40 ml/min/kg
The type 2 diabetic patients:
1. Any other chronic disease than diabetes
2. Blood pressure \> 140/90 mmHg
3. Any chronic medical defect or injury which hinder/interfere everyday life
4. History of anorexia nervosa or bulimia
5. History of rest or exercise-induced asthma
6. Smoking of tobacco, taking of snuffs, or use of narcotics.
7. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
8. Presence of any ferromagnetic objects that would make MRI imaging contraindicated
9. Current or history of regular and systematic exercise training
10. VO2max \>40 ml/ min/kg
40 Years
55 Years
MALE
Yes
Sponsors
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European Foundation for the Study of Diabetes
OTHER
Ministry of Education and Culture, Finland
OTHER
Orion Farmos Research Foundation
UNKNOWN
Academy of Finland
OTHER
Turku PET Centre
UNKNOWN
University of Turku
OTHER
Verve Research, Oulu, Finland
OTHER
University of Helsinki
OTHER
Turku University Hospital
OTHER_GOV
Responsible Party
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Jarna Hannukainen, Turku PET Centre
Locations
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Turku PET Centre
Turku, , Finland
Countries
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Facility Contacts
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Jarna C Hannukainen, PhD
Role: primary
References
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Ojala R, Motiani KK, Ivaska KK, Arponen M, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Heiskanen MA, U-Din M, Nuutila P, Kalliokoski KK, Hannukainen JC. Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training. J Clin Endocrinol Metab. 2020 Dec 1;105(12):e4290-303. doi: 10.1210/clinem/dgaa516.
Motiani KK, Collado MC, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Salminen S, Nuutila P, Kalliokoski KK, Hannukainen JC. Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia. Med Sci Sports Exerc. 2020 Jan;52(1):94-104. doi: 10.1249/MSS.0000000000002112.
Heiskanen MA, Motiani KK, Mari A, Saunavaara V, Eskelinen JJ, Virtanen KA, Koivumaki M, Loyttyniemi E, Nuutila P, Kalliokoski KK, Hannukainen JC. Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial. Diabetologia. 2018 Aug;61(8):1817-1828. doi: 10.1007/s00125-018-4627-x. Epub 2018 May 2.
Other Identifiers
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95/180/2010
Identifier Type: -
Identifier Source: org_study_id