Effect of Acute Exercise on Endothelial Function in Patients With Type 1 Diabetes.
NCT ID: NCT01899872
Last Updated: 2013-07-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
15 participants
INTERVENTIONAL
2011-12-31
2013-12-31
Brief Summary
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Detailed Description
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The endothelial function will be evaluated by vascular reactivity of the forearm and circulating endothelial progenitor cells (EPC) counting. To analyze the vascular reactivity of the forearm, non-invasive venous occlusion plethysmography will be used, whereas flow cytometry method will be used to the analysis of the number of circulating EPC. The endurance exercise session will consist of 40 minutes of cycling on heart rate corresponding to 60% of VO2 max. The resistance exercise session will last 40 minutes, consisting of 4 sets of 12 repetitions at 60% of 1RM, in four exercises for lower limbs. The research will be performed at the Exercise Pathophysiology Research Laboratory of the Hospital de Clinicas de Porto Alegre. The investigators expect to find greater increase in the number of circulating EPC after the endurance exercise session, when compared to the benefits obtained from a session of resistance exercise. Likewise, it is expected to find greater benefits in relation to vascular reactivity of the forearm after a session of endurance exercise when compared to a session of resistance exercise. Considering that most part of the studies that analyze the effects of physical exercise on vascular function does not involve patients with DM1, this project aims to provide a clearer picture of the benefits of different exercises in the acute response of endothelial function in these patients.
Conditions
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Study Design
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NA
SINGLE_GROUP
PREVENTION
SINGLE
Study Groups
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Patients with type 1 diabetes
Patients with type 1 diabetes
Resistance exercise session
Resistance exercise session consisting of 4 lower-limb exercises, with 4 sets, 12 repetitions per set, at an intensity of 60% of maximal strength.
Aerobic exercise session
Aerobic exercise session consisting of 40 minutes of lower-limb bicycle.
Interventions
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Resistance exercise session
Resistance exercise session consisting of 4 lower-limb exercises, with 4 sets, 12 repetitions per set, at an intensity of 60% of maximal strength.
Aerobic exercise session
Aerobic exercise session consisting of 40 minutes of lower-limb bicycle.
Eligibility Criteria
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Inclusion Criteria
* Male gender
* 18-45 years old
Exclusion Criteria
* Diabetic nephropathy established
* Chronic kidney failure
* Limb amputation
* Disabling peripheral arterial disease
* Coronary artery disease
* Heart failure
* Diabetic proliferative retinopathy
* Neoplasms
* Smokers
* Regular physical training
18 Years
45 Years
MALE
No
Sponsors
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Hospital de Clinicas de Porto Alegre
OTHER
Responsible Party
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Beatriz D'Agord Schaan
Beatriz D'Agord Schaan
Locations
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Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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100400
Identifier Type: -
Identifier Source: org_study_id
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