Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
168 participants
INTERVENTIONAL
2023-10-01
2027-11-30
Brief Summary
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Undertaking regular exercise is an obvious strategy for those with T1D and has many well-established health benefits. Despite these benefits, adults with T1D exercise less frequently due to fear of severe hypoglycemia and a lack of knowledge of effective exercise strategies. Adding to this complexity, the investigators have recently shown that males and females elicit differential impairments in skeletal muscle metabolism in response to T1D. These differences may extend to the peripheral microvasculature and may lead to sexual dimorphism in the health benefits of exercise for those with T1D. Ultimately, developing a healthy muscle mass, including microvasculature, will help mitigate dysglycemic and dyslipidemic fluctuations and improve insulin sensitivity.
The overarching purpose of this proposed study is to determine the impact of T1D on human skeletal muscle and its microvasculature over the lifespan in males and females, and its responses to exercise training and detraining.
Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
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Twelve-week Exercise
Study participants will participate in an exercise program consisting of aerobic and resistance exercise. This arm will last twelve weeks.
Exercise
Exercise training.
One-week Detraining
Study participants will undergo unilateral knee immobilization for a one-week period.
De-training
Exercise de-training via unilateral knee immobilization.
Four-week Re-training
Study participants will once again participate in an exercise program consisting of aerobic and resistance exercise. This arm will last four weeks.
Exercise
Exercise training.
Interventions
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Exercise
Exercise training.
De-training
Exercise de-training via unilateral knee immobilization.
Eligibility Criteria
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Inclusion Criteria
* Sedentary or recreationally active, as defined by self-reported activity levels below the recommended 150-minute minimum of moderate-to-vigorous intensity physical activity per week
Exclusion Criteria
* History of daily cannabis, tobacco, or nicotine use within six months of study initiation
* BMI \>30kg/m2
* Prediabetes
* Type 2 diabetes
* Health conditions that put the subject at risk to participate in exercise during this study
* Atypical or Grade 2b diabetic sensorimotor polyneuropathy
* More than one lifetime event of hospitalization for diabetic ketoacidosis
18 Years
65 Years
ALL
Yes
Sponsors
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McMaster University
OTHER
Responsible Party
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Thomas Hawke
Professor
Principal Investigators
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Thomas J Hawke, PhD
Role: PRINCIPAL_INVESTIGATOR
McMaster University
Locations
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McMaster University
Hamilton, Ontario, Canada
Countries
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Central Contacts
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Facility Contacts
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Rebecca Leone
Role: primary
Thomas J Hawke, PhD
Role: backup
Irena A Rebalka, PhD
Role: backup
Maureen MacDonald, PhD
Role: backup
References
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Rebalka IA, Noguchi KS, Bulyovsky KR, Badour MI, Juracic ES, Barrett K, Brahmbhatt A, Al-Khazraji B, Punthakee Z, Perry CGR, Kumbhare DA, MacDonald MJ, Hawke TJ. Targeting skeletal muscle health with exercise in people with type 1 diabetes: A protocol for HOMET1D, a prospective observational trial with matched controls. PLoS One. 2024 May 22;19(5):e0303448. doi: 10.1371/journal.pone.0303448. eCollection 2024.
Other Identifiers
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15516
Identifier Type: -
Identifier Source: org_study_id