Fasted Exercise in People With Type 1 Diabetes

NCT ID: NCT03544684

Last Updated: 2018-06-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 14 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2015-03-09
• Study Completion Date: 2017-10-10

Brief Summary

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period.

Detailed Description

This study aims to compare the effect of a bout of high-intensity interval training (HIT) with a bout of moderate-intensity continuous training (MICT) on glucose concentrations over the subsequent 24h period. Fourteen people with type 1 diabetes (duration of type 1 diabetes 8.2±1.4 years), all on basal-bolus regimen, completed a randomised, counterbalanced, crossover study. Continuous glucose monitoring was used to assess glycaemic control following a single bout of HIT (6 x 1min intervals) and 30 mins of moderate-intensity continuous training (MICT) on separate days, compared to a non-exercise control day (CON). Exercise was undertaken following an overnight fast with omission of short-acting insulin. Capillary blood glucose samples were recorded pre and post-exercise to assess the acute changes in glycaemia during HIT and MICT.

Conditions

Type1diabetes

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Control day with no exercise

glycaemic profile will be assessed using continuous glucose monitors following a single 24-hour period in which participants performed no exercise

Group Type: EXPERIMENTAL

Effects of the type of exercise on blood glucose concentrations

Intervention Type: BEHAVIORAL

glucose concentrations were assessed over the 24 hour periods following no exercise, a single bout of high intensity interval training and a single bout of moderate intensity continuous training

High intensity interval training (HIT)

glycaemic profile will be assessed using continuous glucose monitors following a 24-hour period whereby participants performed a single bout of high-intensity interval training (HIT) in the morning under fasted conditions

Group Type: EXPERIMENTAL

Effects of the type of exercise on blood glucose concentrations

Intervention Type: BEHAVIORAL

glucose concentrations were assessed over the 24 hour periods following no exercise, a single bout of high intensity interval training and a single bout of moderate intensity continuous training

moderate intensity continuous training (MICT)

glycaemic profile will be assessed using continuous glucose monitors following a 24-hour period whereby participants performed a single bout of moderate-intensity continuous training (MICT) in the morning under fasted conditions

Group Type: EXPERIMENTAL

Effects of the type of exercise on blood glucose concentrations

Intervention Type: BEHAVIORAL

glucose concentrations were assessed over the 24 hour periods following no exercise, a single bout of high intensity interval training and a single bout of moderate intensity continuous training

Interventions

Effects of the type of exercise on blood glucose concentrations

glucose concentrations were assessed over the 24 hour periods following no exercise, a single bout of high intensity interval training and a single bout of moderate intensity continuous training

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• duration of type 1 diabetes >6 months
• basal bolus regimen
• no significant history of hyper- or hypoglycaemia (determined from medical history

Exclusion Criteria

• duration of type 1 diabetes <6 months,
• insulin pump therapy
• significant history of hyper- or hypoglycaemia (determined from medical history)
• obesity (BMI >30 kg∙m-2)
• pregnancy or planning pregnancy, uncontrolled hypertension (>180/100 mmHg)
• angina
• autonomic neuropathy
• taking any medication that affects heart rate
• major surgery planned within 6 weeks of the study
• severe nonproliferative and
• unstable proliferative retinopathy

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Liverpool John Moores University

OTHER

Sponsor Role: lead

Responsible Party

Sam Shepherd

Lecturer/Senior Lecturer, Principle Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Liverpool John Moores University

Liverpool, Merseyside, United Kingdom

Countries

United Kingdom

References

Scott SN, Cocks M, Andrews RC, Narendran P, Purewal TS, Cuthbertson DJ, Wagenmakers AJM, Shepherd SO. High-Intensity Interval Training Improves Aerobic Capacity Without a Detrimental Decline in Blood Glucose in People With Type 1 Diabetes. J Clin Endocrinol Metab. 2019 Feb 1;104(2):604-612. doi: 10.1210/jc.2018-01309.

Reference Type: DERIVED

PMID: 30281094 (View on PubMed)

Scott SN, Cocks M, Andrews RC, Narendran P, Purewal TS, Cuthbertson DJ, Wagenmakers AJM, Shepherd SO. Fasted High-Intensity Interval and Moderate-Intensity Exercise Do Not Lead to Detrimental 24-Hour Blood Glucose Profiles. J Clin Endocrinol Metab. 2019 Jan 1;104(1):111-117. doi: 10.1210/jc.2018-01308.

Reference Type: DERIVED

PMID: 30252054 (View on PubMed)

Other Identifiers

T1D_PARTA

Identifier Type: -

Identifier Source: org_study_id