Exercising in Hot Conditions: How Does it Effect Blood Glucose in People With T1D

NCT ID: NCT07341243

Last Updated: 2026-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-11-01

Study Completion Date

2026-11-01

Brief Summary

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A randomised, crossover, counterbalanced repeated measures study will be conducted to examine the effect of acute heat exposure on rate of change in blood glucose concentration during 40 minutes of moderate-intensity exercise and for 30 minutes after exercise. Participants will complete two experimental conditions during two separate laboratory visits, with the order of conditions randomised. One condition will be a temperate condition of 20°C with 50% relative humidity (Temperate), the other will be 40°C with 50% relative humidity (Heat). Visits will be identical, including time of day, except for the condition. Visits will be separated by 24h. Testing will take place in the laboratories of the Research Institute for Sport and Exercise Sciences at Liverpool John Moores University.

Detailed Description

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Conditions

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Type 1 Diabetes (T1D)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Temperate

40 minutes of moderate intensity continuous exercise at 20°C with 50% relative humidity

Group Type ACTIVE_COMPARATOR

Exercise

Intervention Type BEHAVIORAL

exercise in the heat or temperate conditions

Heat

40 minutes of moderate intensity continuous exercise at 40°C with 50% relative humidity

Group Type EXPERIMENTAL

Exercise

Intervention Type BEHAVIORAL

exercise in the heat or temperate conditions

Interventions

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Exercise

exercise in the heat or temperate conditions

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* T1D diagnosis more than 1 years ago (to ensure participants are out of the honeymoon period)
* Using insulin therapy with multiple daily injections (MDI), insulin pump (pump), or hybrid closed-loop (HCL)

o If using a HCL system have experience of using a pre-programmed basal rate in manual mode during exercise
* Aged 18-65 years
* Regularly engaged in endurance exercise (training at least twice per week for ≥30 minutes per session)

Exclusion Criteria

* Pregnancy
* \<6 months postpartum or stopped breastfeeding \<1 month before recruitment
* Existing cerebrovascular or cardiovascular disease
* Significant history of hyperglycaemia (HbA1c \>85 mmol/mol)
* History of severe hypoglycaemia requiring third party assistance within the last 3 months
* Body weight \<36.5kg
* Difficulty swallowing tablets
* Appointment for an MRI test that cannot be rescheduled
* Obstructive gastrointestinal disease
* History of gastrointestinal surgery
* Have an implanted medical device
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Liverpool John Moores University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Liverpool John Moores University

Liverpool, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Matthew Cocks, PhD

Role: CONTACT

447540191292

Facility Contacts

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Matthew Cocks, PhD

Role: primary

4407540191292

Other Identifiers

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25/SPS/065

Identifier Type: -

Identifier Source: org_study_id

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