Effect of Post-exercise Nutrition on Glycemia in Women

NCT ID: NCT05876260

Last Updated: 2024-05-07

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-05-24
• Study Completion Date: 2024-05-01

Brief Summary

The purpose of this study is to assess whether post-exercise Greek yogurt following a single session of aerobic exercise improves metabolic and musculoskeletal health in women with overweight/obesity.

Detailed Description

Following the acquisition of informed consent, eligibility to participate in the study will be determined using questionnaires. Participants will undergo baseline testing at our laboratory at the University of Toronto to determine cardiorespiratory fitness, body composition and undergo exercise familiarization.

Eligible participants will be assigned, in a random order, to two metabolic trials approximately 4 weeks apart that involve 4 days of controlled diet and exercise. Each trial takes place over 4 days, but participants are not required to come to the laboratory on all days. The two trials involve: 1) Exercise + Greek Yogurt (GY) 2) Exercise + a carbohydrate-based study supplement (SS).

During the 4 day trials, participants consume controlled diets and the study supplements (GY and SS). On 1 of these days participants will perform exercise in our lab followed by the consumption of GY or SS. Various outcomes will be measured throughout the trial, including glycemic control (via continuous glucose monitoring), fat oxidation, appetite and health outcomes in blood samples.

Throughout the duration of the study, participants will be asked to maintain their habitual diet and physical activity patterns, and maintain their current body weight.

Conditions

Overweight and Obesity

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

High-intensity interval exercise and post-exercise Greek yogurt (HIIE+GY)

Participants will consume greek yogurt following a single session of exercise

Group Type: EXPERIMENTAL

Greek yogurt

Intervention Type: BEHAVIORAL

Following 2 days of controlled diet, participants will consume greek yogurt following high-intensity interval exercise

Exercise

Intervention Type: BEHAVIORAL

Following 2 days of controlled diet, participants will perform high-intensity interval exercise following an overnight fast

High-intensity interval exercise and post-exercise carbohydrate study supplement (HIIE +SS)

Participants will consume a carbohydrate-based study supplement following a single session of exercise

Group Type: ACTIVE_COMPARATOR

Carbohydrate-based study supplement

Intervention Type: BEHAVIORAL

Following 2 days of controlled diet, participants will consume a carbohydrate-based study supplement following high-intensity interval exercise

Exercise

Intervention Type: BEHAVIORAL

Following 2 days of controlled diet, participants will perform high-intensity interval exercise following an overnight fast

Interventions

Greek yogurt

Following 2 days of controlled diet, participants will consume greek yogurt following high-intensity interval exercise

Intervention Type: BEHAVIORAL

Carbohydrate-based study supplement

Following 2 days of controlled diet, participants will consume a carbohydrate-based study supplement following high-intensity interval exercise

Intervention Type: BEHAVIORAL

Exercise

Following 2 days of controlled diet, participants will perform high-intensity interval exercise following an overnight fast

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• 18-45 yrs
• BMI ≥27 kg/m2
• Elevated waist circumference (≥88 cm)
• ≤2 structured exercise sessions/week
• Weight stable (within ± 2kg for at least 6 months)
• Experiencing regular natural menstrual cycles
• Non-smoker

Exclusion Criteria

• Allergy to dairy foods
• Diagnosed lactose intolerance or an aversion to foods provided during the study (e.g., post-exercise snacks)
• Previous history of cardiovascular or metabolic disease
• The use of medication for managing blood glucose or lipid metabolism
• Current use of oral contraceptives or use within the last 3 months
• Irregular menstrual cycles (<21 days or >35 days)
• Pregnant or lactating
• Recreational tobacco or cannabis use
• Inability to perform the study exercise protocols
• Actively engaging in a low-carbohydrate diet (e.g., ketogenic, Atkins).

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Toronto

OTHER

Sponsor Role: lead

Responsible Party

Jenna Gillen

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Jenna Gillen, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Toronto

Locations

Jenna Gillen

Toronto, Ontario, Canada

Countries

Canada

Other Identifiers

42756-3

Identifier Type: -

Identifier Source: org_study_id