Investigation of the Effects of Exercise on Gene Expression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-07-31

Study Completion Date

2007-12-31

Brief Summary

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The investigators have previously shown that mild exercise training at the level of lactate threshold (LT) intensity (60 min/day, 5 days/week) improves peripheral insulin sensitivity and insulin-independent glucose disposal of glucose effectiveness, without changes in body weight and body fat (Nishida et al, Diabetes Care, 2001; Nishida et al, Diabetes, 2004). Thus these beneficial effects are likely related to a number of adaptations that occur in skeletal muscle as response to exercise. In the current study, the investigators hypothesised that a single bout of mild exercise performed at LT would be a physiological stimulator of skeletal muscle PGC-1alpha gene, and the repetition of this exercise stimulating PGC-1alpha gene (i.e., training) for 12 weeks would induce coordinated increases in a large number of metabolic genes, as well as other genes potentially important in the prevention of insulin resistance and metabolic syndrome.

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Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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exercise

mild exercise training

Group Type EXPERIMENTAL

exercise training

Intervention Type OTHER

60 min of low-intensity exercise, 5 days/week, 12 weeks

Interventions

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exercise training

60 min of low-intensity exercise, 5 days/week, 12 weeks

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Men who were all in good health
* All individuals were free from diabetes and none were taking any medications
* All subjects were asked not to change their normal dietary habits, and not to engage in any strenuous physical activity