Nutrient Synergy in Beef and Stimulation of Protein Synthesis in Elderly

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-07-31

Study Completion Date

2012-01-31

Brief Summary

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This study will compare the effects of cooked, ground beef to those of beef protein isolate on blood and muscle proteins.

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Detailed Description

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STUDY OBJECTIVES Primary: To compare the effects of consumption of a 3-ounce serving of beef to that of a 20g serving of BPI on skeletal muscle synthetic and breakdown rate in healthy elderly subjects.

Secondary: To investigate the effect the study products on plasma levels of amino acids, insulin, and glucose in healthy elderly subjects.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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3 ounces of cooked, 85% lean ground beef

Subjects would consume 3 ounces of cooked, 85% lean ground beef at one setting on one day.

Group Type EXPERIMENTAL

3 ounces of cooked, 85% lean ground beef

Intervention Type DIETARY_SUPPLEMENT

Consumed once per subject.

20 grams of Beef protein isolate

Subjects would consume 20 grams of beef protein isolate dissolved into 200mL water at one setting on one day.

Group Type EXPERIMENTAL

20 grams beef protein isolate

Intervention Type DIETARY_SUPPLEMENT

Subjects would drink 200 ml water mixed with 20 grams of beef protein isolate one time.

Interventions

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3 ounces of cooked, 85% lean ground beef

Consumed once per subject.

Intervention Type DIETARY_SUPPLEMENT

20 grams beef protein isolate

Subjects would drink 200 ml water mixed with 20 grams of beef protein isolate one time.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Healthy male or female.
* Age 60 years or older.

Exclusion Criteria

* Any (history of) gastrointestinal disease that interferes with GI function
* Diagnosed and active treatment of Diabetes Mellitus type I or II
* History of congestive heart failure
* Recent (6 months) hospitalization for heart disease treatment or management (e.g. PTCA, stent, surgery)
* Myocardial infarction in the past year
* Infection or fever in the 7 days prior to enrollment
* Current use of corticosteroids, growth hormone, or testosterone
* Adherence to a weight loss diet
* Use of protein-containing or amino acid-containing nutritional supplements within one week of enrollment
* Current alcohol (\>7 ETOH per week) or drug abuse
* Platelet count (PLT) \< 100,000
* History of hypo- or hyper-coagulation disorders including use of a coumadin derivative
* Currently taking anti-thrombotics and cannot stop for 7 days (i.e. medical indication)
* Allergy to local anesthetic
* Blood hemoglobin \< 9.0 g/dL
* Investigator's uncertainty about the willingness or ability of the subject to comply with the protocol requirements

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes