Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women
NCT ID: NCT02918981
Last Updated: 2020-11-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
50 participants
INTERVENTIONAL
2016-10-31
2019-03-06
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Whey protein
After resistance exercise, participants aged 50-79 years will consume 14g Whey protein dissolved in 200 mL of water
Resistance Exercise
Participants will perform unilateral leg extension exercise immediately prior to ingestion of the experimental beverage
14 g Whey protein
Whey + Leucine
After resistance exercise, participants aged 50-79 years will consume 6.6 g Whey protein + 1.25 g Leucine dissolved in 200 mL of water
Resistance Exercise
Participants will perform unilateral leg extension exercise immediately prior to ingestion of the experimental beverage
6.6 g Whey protein + 1.25 g leucine
Whey + Leucine + Whey peptides
After resistance exercise, participants aged 50-79 years will consume 4 g Whey protein + 1.25 g Leucine + 2.6 g Whey peptides dissolved in 200 mL of water
Resistance Exercise
Participants will perform unilateral leg extension exercise immediately prior to ingestion of the experimental beverage
4 g Whey protein + 1.25 g leucine + 2.6 g Whey peptides
Whey + Leucine + Citrulline
After resistance exercise, participants aged 50-79 years will consume 6.6 g Whey protein + 1.25 g Leucine + 0.8 g Citrulline dissolved in 200 mL of water
Resistance Exercise
Participants will perform unilateral leg extension exercise immediately prior to ingestion of the experimental beverage
6.6 g Whey protein + 1.25 g leucine + 0.8 g Citrulline
Water
After resistance exercise, participants aged either 20-30 or 50-79 years old will consume 200 mL water
Resistance Exercise
Participants will perform unilateral leg extension exercise immediately prior to ingestion of the experimental beverage
Water control
Interventions
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Resistance Exercise
Participants will perform unilateral leg extension exercise immediately prior to ingestion of the experimental beverage
14 g Whey protein
6.6 g Whey protein + 1.25 g leucine
4 g Whey protein + 1.25 g leucine + 2.6 g Whey peptides
6.6 g Whey protein + 1.25 g leucine + 0.8 g Citrulline
Water control
Eligibility Criteria
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Inclusion Criteria
* Healthy, sedentary
* Either 20-30 years old or 50-79 years old
Exclusion Criteria
* Allergies to milk consumption
* Unusually high protein consumption
* Vegan diet
* Allergies to antibiotics or xylocaine
* Phenylketonuria (PKU)
* Diagnosed GI tract diseases
* Arthritic conditions
* A history of neuromuscular problems
* Heart disease
* Metabolic disorders
* -Liver, kidney, or urinary disease
* Musculoskeletal problems
* Autoimmune disease
* Neurological disease
* Previous participation in amino acid tracer studies
* Predisposition to hypertrophic scarring or keloid formation
* Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
* Individuals using thyroid medications or other medications affecting endocrine function
* Pregnancy
* Contraindications for exercise
* BMI ≥30
* supplements that influence protein metabolism (e.g omega 3 fish oils)
20 Years
79 Years
FEMALE
Yes
Sponsors
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University of Illinois at Urbana-Champaign
OTHER
Responsible Party
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Nicholas Burd
Assistant Professor
Principal Investigators
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Nicholas A Burd, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
University of Illinois at Chicago
Locations
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Freer Hall
Urbana, Illinois, United States
Countries
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Other Identifiers
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16999
Identifier Type: -
Identifier Source: org_study_id