Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
30 participants
INTERVENTIONAL
2023-07-10
2024-12-31
Brief Summary
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AIM 1: To test the hypothesis that muscle fatigue is attenuated in older adults consuming beef compared to older adults consuming a plant-based diet.
AIM2: To test the hypothesis that daily beef consumption improves biochemical indicators related to muscle fatigue.
Participants will be randomized to consume either a beef-based diet or vegetarian diet under controlled-feeding conditions for 8 weeks. After a 2-week washout period, participants will cross-over to consume either the beef diet or vegetarian diet for 8 weeks. Body composition and functional muscle outcomes will be measured during each 8-week feeding period. Blood samples will also be collected.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
TRIPLE
Study Groups
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Beef Diet
Participants will be randomized to consume the beef diet for 8 weeks. After a 2-week period, participants will cross-over to consume the vegetarian diet for 8 weeks.
Beef Diet
Controlled-Feeding Diet Intervention
Vegetarian Diet
Participants will be randomized to consume the vegetarian diet for 8 weeks. After a 2-week period, participants will cross-over to consume the beef diet for 8 weeks.
Vegetarian Diet
Controlled-Feeding Diet Intervention
Interventions
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Beef Diet
Controlled-Feeding Diet Intervention
Vegetarian Diet
Controlled-Feeding Diet Intervention
Eligibility Criteria
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Inclusion Criteria
* Ability to eat study diet meals for a total of 16 weeks
* Ability to perform sit-to-stand chair and 6-minute walking tests based on results from PAR-Q questionnaire
* Ability to provide fasted blood samples
* Access to transportation
* Willing to abstain from alcohol consumption and/or use illicit drug use for each 8-week intervention period
* Ability to consent to participating in this study
* English-speaking
* Body mass index between 18.5 (normal) and 39.9 (obese) kg/m2
* Minimum total body weight of 110 pounds
* Non-anemia hemoglobin values: Females - \>12.0 grams/dL; Men - \>13.0 grams/dL
* Able to ambulate without assistance
* Physician's clearance for study participation (required prior to baseline testing)
Exclusion Criteria
* Significant orthopedic limitations or other contraindications to exercise
* Inability or refusal to perform muscle fatigue tests
* Has dietary restrictions that prevent to consumption of beef, soy and/or wheat
* Has liver or kidney complications
* Live or work \>25 miles from Bloomington study site or does not have transportation to the study site
* Anticipate elective surgery during the study period
* Diagnosis of progressive neurological disorders, musculoskeletal disorders, osteoarthritis, rheumatoid arthritis
* Fracture or serious injury in the last 6 months
* Stroke, revascularization, deep vein thrombosis, or pulmonary embolism in the past 12 months
* Severe cardiovascular disease, uncontrolled systemic hypertension, chronic pulmonary disease
* Plan to move residence or travel out of the local area during the study period
* Current use of anti-coagulants (e.g. Coumadin or Warfarin)
* Current use of prescription medications that affect heart rate or blood vessel dilation
* Psychological or social characteristics that would interfere with their ability to fully participate in the study
60 Years
85 Years
ALL
Yes
Sponsors
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Indiana University
OTHER
Responsible Party
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Cydne Perry
Assistant Professor Applied Health Sciences
Principal Investigators
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Cydne A Perry, PhD
Role: PRINCIPAL_INVESTIGATOR
Indiana University, Bloomington
Locations
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Indiana University Bloomington
Bloomington, Indiana, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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14941
Identifier Type: -
Identifier Source: org_study_id
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