The Effect of the DASH Diet Containing Meat on Muscle and Metabolic Health in Older Adults

NCT ID: NCT04127240

Last Updated: 2019-10-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 46 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-06-15
• Study Completion Date: 2018-11-10

Brief Summary

Age-related changes in body composition, muscular fitness, and metabolic health resulting in the onset of obesity, sarcopenia, and chronic diseases are profound public health issues that are in need of immediate attention. Effective and feasible methods, such as dietary therapies, are needed to improve health in older adults that in turn lead to independence, enhanced quality of life and reduced hospitalizations. Diet quality and dietary protein intake are vital for maintaining body composition, muscle mass and improved physical performance. Malnutrition in dietary protein intake is a major cause of reduced muscle mass, strength, and function in older adults. The Dietary Approaches to Stop Hypertension (DASH) dietary pattern is a high-quality therapeutic diet known to improve health status in various diverse and at-risk populations resulting in improved heart health, maintained cognitive function and reductions in metabolic diseases such as diabetes, metabolic syndrome, and nonalcoholic fatty liver disease. The primary protein recommendations of the DASH diet are poultry and fish and it is recommended to decrease or exclude red meats from the diet. However, studies have demonstrated that lean red meat incorporated into a DASH-like diet doesn't exacerbate cardiovascular health indices in adults, indicating that lean red meat can be included in the DASH diet without negative effects on heart health. Although studies have reported on the DASH diet in older adults, no studies have investigated the effect of the DASH diet containing lean red meat on measures of body composition, muscle mass or metabolic health under controlled-feeding conditions. The purpose of this study was to determine the effect of the DASH diet containing daily intakes of lean red meat on indicators of body composition, muscular fitness and biomarkers of metabolic health in adults 65 and older using controlled-feeding and systems biology approaches.

Conditions

Obesity; Sarcopenia; Aging

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: SINGLE

Study Groups

Meat assignment in DASH intervention

Participants consumed 3 ounces of red meat per day as a part of the DASH diet.

Group Type: EXPERIMENTAL

DASH diet containing daily intakes of red meat

Intervention Type: OTHER

Each participant was randomized to consume 3 or 6 ounces of red meat as a part of the DASH dietary pattern for 12-weeks.

Meat allocation in DASH intervention

Participants consumed 6 ounces of red meat per day as a part of the DASH diet.

Group Type: EXPERIMENTAL

DASH diet containing daily intakes of red meat

Intervention Type: OTHER

Each participant was randomized to consume 3 or 6 ounces of red meat as a part of the DASH dietary pattern for 12-weeks.

Interventions

DASH diet containing daily intakes of red meat

Each participant was randomized to consume 3 or 6 ounces of red meat as a part of the DASH dietary pattern for 12-weeks.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 65 and older
• Upward mobile ability

Exclusion Criteria

• Under the age of 65
• Immobility

• Minimum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

South Dakota State University

OTHER

Sponsor Role: lead

Responsible Party

Cydne Perry

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Cydne A Perry, PhD

Role: PRINCIPAL_INVESTIGATOR

South Dakota State University

Locations

South Dakota State University

Brookings, South Dakota, United States

Countries

United States

References

Perry CA, Van Guilder GP, Butterick TA. Decreased myostatin in response to a controlled DASH diet is associated with improved body composition and cardiometabolic biomarkers in older adults: results from a controlled-feeding diet intervention study. BMC Nutr. 2022 Mar 15;8(1):24. doi: 10.1186/s40795-022-00516-9.

Reference Type: DERIVED

PMID: 35287731 (View on PubMed)

Other Identifiers

1712006

Identifier Type: -

Identifier Source: org_study_id