Effectiveness of Creatine Supplementation and Exercise on Muscle and Bone

NCT ID: NCT01057680

Last Updated: 2012-12-27

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE3
• Total Enrollment: 90 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-01-31
• Study Completion Date: 2012-02-29

Brief Summary

As we age, we experience a reduction in muscle and bone which inevitably decreases strength and the ability to perform tasks of daily living such as gardening, carrying groceries, and climbing stairs. Health costs associated with aging muscle and bone loss are in the billions of dollars. With the projected increase in life expectancy, the incidence of muscle and bone loss will rise and further drain the healthcare system, with greater need for hospitalization, treatment, and rehabilitation. Without effective strategies to counteract aging muscle and bone loss, we may face a healthcare crisis in the future. Creatine, a compound found in red meat and seafood, increases creatine phosphate stores in muscle, providing increased energy during high-intensity exercise. Short-term (i.e. 3-4 months) resistance-exercise and supplementation with creatine, have been shown to have a favorable effect on properties of aging muscle and bone. However, the longer-term (i.e. 1 year) effects of these interventions are unknown. Therefore, the purpose of this innovative research is to determine the longer-term effects of resistance-exercise and creatine supplementation (0.1g•kg-1) in older adults. The primary dependent variables to be assessed will include muscle hypertrophy, bone mineral and bone geometry, strength, and urinary and blood indicators of liver and kidney function. This innovative, multidisciplinary research will help contribute to the successful pursuit of prolonged independent living by improving aging musculoskeletal health for older Saskatchewan adults. Saskatchewan provides a relevant setting for this research, given the higher percentage of older adults (15%), compared to the national average (12%).

We hypothesize that creatine supplementation will increase muscle mass, strength, and bone mineral density more than placebo.

Conditions

Osteoporosis; Sarcopenia

Keywords

Bone; Muscle; Strength; Kidney; Liver; Creatine

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: TRIPLE

Study Groups

creatine

This arm will involve creatine supplementation 0.1 g per kg body mass per day while participating in a resistance training program (1 hour per day, 3 days per week).

Group Type: EXPERIMENTAL

creatine monohydrate

Intervention Type: DIETARY_SUPPLEMENT

Powder, 0.1 g per day, 12 months

Sugar

This arm will involve placebo (maltodextrin) given every day while the participant does a resistance training program (1 hour per day, 3 days per week).

Group Type: PLACEBO_COMPARATOR

sugar placebo

Intervention Type: DIETARY_SUPPLEMENT

powder, 0.1 g/day, 12 months

Interventions

creatine monohydrate

Powder, 0.1 g per day, 12 months

Intervention Type: DIETARY_SUPPLEMENT

sugar placebo

powder, 0.1 g/day, 12 months

Intervention Type: DIETARY_SUPPLEMENT

Other Intervention Names

Rivalus

Eligibility Criteria

Inclusion Criteria

• greater than or equal to 50 years of age
• males or postmenopausal females
• not currently participating in resistance training

Exclusion Criteria

• pre-existing kidney abnormalities
• previous fragility fractures
• history of taking medications that affect bone mineral density in the past year including bisphosphonates, parathyroid hormone, calcitonin, hormone replacement therapy, or corticosteroids (i.e. within the past year)
• suffer from severe osteoarthritis
• have taken creatine supplementation within the past 6 months

• Minimum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University of Saskatchewan

OTHER

Sponsor Role: lead

Responsible Party

Phil Chilibeck

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Philip Chilibeck, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Saskatchewan

Darren Candow, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

University of Regina

Locations

Faculty of Kinesiology and Health Sciences

Regina, Saskatchewan, Canada

College of Kinesiology, University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Countries

Canada

References

Candow DG, Chilibeck PD, Gordon JJ, Kontulainen S. Efficacy of Creatine Supplementation and Resistance Training on Area and Density of Bone and Muscle in Older Adults. Med Sci Sports Exerc. 2021 Nov 1;53(11):2388-2395. doi: 10.1249/MSS.0000000000002722.

Reference Type: DERIVED

PMID: 34107512 (View on PubMed)

Other Identifiers

09-169

Identifier Type: -

Identifier Source: org_study_id