Effects of Beef Consumption on Skeletal Muscle Protein Homeostasis and Inflammatory Factors in Pre- and Postmenopausal Females

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

65 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-08-28

Study Completion Date

2025-04-01

Brief Summary

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This will be a randomized study to determine if animal-based protein-rich food sources can stimulate greater muscle protein turnover and whole-body protein balance and reduce skeletal muscle inflammatory markers in postmenopausal women compared to vegetarian base protein-rich foods.

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Detailed Description

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A randomized cross-sectional controlled trial will be conducted to quantify whole-body and muscle protein turnover and skeletal muscle inflammation following 5-days of consumption of either beef or isonitrogenous plant-based sources of protein in normal/overweight and obese post-menopausal females. A premenopausal normal/overweight group consuming beef containing study meals will also be recruited to serve as a healthy control comparison.

Conditions

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Menopause Related Conditions

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

A randomized cross-sectional controlled trial will be conducted to quantify whole-body and muscle protein turnover and skeletal muscle inflammation following 5-days of consumption of either beef or isonitrogenous plant-based sources of protein in normal/overweight and obese post-menopausal females.

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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postmenopausal with normal/overweight BMI that eats primarily beef as their protein source

Group Type EXPERIMENTAL

meals consisting of primarily animal protein sources

Intervention Type OTHER

an omnivorous diet

postmenopausal with normal/overweight BMI that eats vegetables as their protein source

Group Type EXPERIMENTAL

meals consisting of plant protein sources

Intervention Type OTHER

an herbivorous diet

postmenopausal with obese BMI that eats primarily beef as their protein source in study meals

Group Type EXPERIMENTAL

meals consisting of primarily animal protein sources

Intervention Type OTHER

an omnivorous diet

postmenopausal with obese BMI that eats vegetables as their protein source in study meals

Group Type EXPERIMENTAL

meals consisting of plant protein sources

Intervention Type OTHER

an herbivorous diet

premenopausal with normal/overweight BMI that eats primarily beef as their protein source

Group Type ACTIVE_COMPARATOR

meals consisting of primarily animal protein sources

Intervention Type OTHER

an omnivorous diet

Interventions

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meals consisting of primarily animal protein sources

an omnivorous diet

Intervention Type OTHER

meals consisting of plant protein sources

an herbivorous diet

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Postmenopausal women ages 50-65 (absence of menstruation for at least 12 months).
2. Premenopausal women ages 35-45 (presence of normal monthly menstruation for the past 12 months).
3. BMI of 20.0 - 34.9 kg/m2.
4. COVID-19 negative and/or asymptomatic

Exclusion Criteria

1. Any substantial musculoskeletal injuries/diseases that have limited daily activities in the past month.
2. Unable to stop the use of anti-inflammatory drugs for the week prior to and during study.
3. Diagnosed metabolic or hormonal disease (i.e., renal, cardiovascular, thyroid, polycystic ovary syndrome, or type I/II diabetes mellitus).
4. Currently pregnant.
5. Gave birth or was lactating within previous 12 months.
6. Undergone gastric bypass/bariatric surgery.
7. Clinically significant weight gain or loss (\>5% change) in the last 12 months.
8. Consuming metabolism-altering drugs or medications (i.e., corticosteroids, stimulants, insulin, thyroid medication).
9. Unable or unwilling to suspend anti-clotting medications including aspirin use for 5 days prior to Visit 4.
10. Participating in \>200 minutes/week of vigorous exercise and/or \>4 days/week of resistance training.
11. Unwilling to fast overnight.
12. Surgical menopause.
13. Having undergone hormone replacement therapy in the last 12 months.

Minimum Eligible Age

35 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes