Protein Eating Patterns and Weight Loss

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-02

Study Completion Date

2023-04-14

Brief Summary

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The purpose of this study is to determine the effects of daily protein intake patterns on body composition and eating behaviors during weight loss.

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Detailed Description

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The reinforcing value of food varies greatly among individuals, but is strongest for those who are overweight or obese. Reducing energy intake, which is necessary for overweight and obese individuals to achieve a healthier body weight, increases the reinforcing value of food - especially for energy-dense snack foods. Food is a powerful reinforcer and is associated with energy intake; making it a primary contributing factor to an individual's weight loss struggle. Developing a way to decrease or limit the increase in food reinforcement during energy deficits would have important clinical impact. High-protein diets are known to be efficacious for weight loss and recently have been shown to decrease stimulation of the reward areas of the brain that stimulate reward-driven eating behavior. Nonetheless, sustaining a high-protein diet can be difficult, especially for women. Consuming a modest amount of protein at each meal may be better tolerated. However, we do not know whether this pattern of protein intake can assist women in staying "on track" with weight loss goals. This study will help begin to elucidate the connections between the daily pattern of protein intake on diet adherence, alterations in food reinforcement, and favorable body composition changes during weight loss.

Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Even protein intake

Menu to provide 90 g of protein per day in an even distribution of 30 g at each meal.

Group Type EXPERIMENTAL

Even protein

Intervention Type OTHER

Intake of even protein 5 day rotating menu

Skewed protein intake

Menu to provide 90 g of protein per day in a skewed distribution of 10 g at breakfast, 15 g at lunch and 65 g at dinner.

Group Type EXPERIMENTAL

Skewed protein

Intervention Type OTHER

Intake of skewed protein 5 day rotating menu

Interventions

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Even protein

Intake of even protein 5 day rotating menu

Intervention Type OTHER

Skewed protein

Intake of skewed protein 5 day rotating menu

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI 28-45 kg/m2

Exclusion Criteria

* unable or unwilling to consume animal products
* unable or unwilling to attend treatment group meetings
* had more than a 10% change in body weight in the 2 months prior to study start date
* consuming a specialized diet
* have a history of and eating or gastrointestinal disorder
* currently or planning on becoming pregnant during the study timeline
* lactating
* have an uncontrolled metabolic illness/disease (fasting glucose \>125 mg/dL)
* have uncontrolled hypertension (\>160/99 mm Hg)
* have cancer or in short-term remission (less than 3 years)
* have an infectious disease
* suffer from alcohol or drug abuse
* use tobacco and/or e-cigarette products on a regular basis
* taking medications known to affect energy expenditure and appetite

Minimum Eligible Age

20 Years

Maximum Eligible Age

44 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes