Optimal Protein Dose Per Meal During Weight Loss in Perspective to Maintaining Muscle Mass
NCT ID: NCT03326284
Last Updated: 2019-07-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
40 participants
INTERVENTIONAL
2017-08-01
2018-02-01
Brief Summary
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Detailed Description
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The hypothesis is that the optimum dose of protein for women on a hypocaloric diet will be greater than when women eat an energy sufficient diet, and also higher than the optimal dose previously determined in weight stable men.
Methods: Forty women (\~ 50 years) will be randomized to four groups. Following a five day hypocaloric diet (three groups) or an energy balanced diet (one group). The women will report to the laboratory to ingest one of three different protein doses. The muscle protein response to the different doses of protein will be determined by the muscle protein fractional synthetic rates using tracer kinetics.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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15g protein hypocaloric diet
Following a 5-day hypocaloric diet the subjects (n=10) will ingest 15g of protein and their mixed muscle protein synthesis response will be monitored using tracer kinetics.
15 g protein hypocaloric
Following a 5 day hypocaloric diet one group of 10 women will ingest 15 g of protein
35g protein hypocaloric diet
Following a 5-day hypocaloric diet the subjects (n=10) will ingest 35g of protein and their mixed muscle protein synthesis response will be monitored using tracer kinetics.
35 g protein hypocaloric
Following a 5 day hypocaloric diet one group of 10 women will ingest 35 g of protein
60g protein hypocaloric diet
Following a 5-day hypocaloric diet the subjects (n=10) will ingest 60g of protein and their mixed muscle protein synthesis response will be monitored using tracer kinetics.
60 g protein hypocaloric
Following a 5 day hypocaloric diet one group of 10 women will ingest 60 g of protein
35g protein energy balanced diet
Following a 5-day energy balanced diet the subjects (n=10) will ingest 35g of protein and their mixed muscle protein synthesis response will be monitored using tracer kinetics.
35 g protein energy balance
Following a 5 day energy balanced diet one group of 10 women will ingest 35 g of protein
Interventions
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15 g protein hypocaloric
Following a 5 day hypocaloric diet one group of 10 women will ingest 15 g of protein
35 g protein hypocaloric
Following a 5 day hypocaloric diet one group of 10 women will ingest 35 g of protein
60 g protein hypocaloric
Following a 5 day hypocaloric diet one group of 10 women will ingest 60 g of protein
35 g protein energy balance
Following a 5 day energy balanced diet one group of 10 women will ingest 35 g of protein
Eligibility Criteria
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Inclusion Criteria
* Postmenopausal women
Exclusion Criteria
* Metabolic and/or chronic diseases
45 Years
75 Years
FEMALE
Yes
Sponsors
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Arla Foods
INDUSTRY
Innovation foundation
UNKNOWN
Mejeribrugets ForskningsFond
OTHER
University of Aarhus
OTHER
Responsible Party
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Locations
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Aarhus University, Department for Public Health, Section for Sport Science
Aarhus, , Denmark
Countries
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References
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Larsen MS, Witard OC, Holm L, Scaife P, Hansen R, Smith K, Tipton KD, Mose M, Bengtsen MB, Lauritsen KM, Mikkelsen UR, Hansen M. Dose-Response of Myofibrillar Protein Synthesis To Ingested Whey Protein During Energy Restriction in Overweight Postmenopausal Women: A Randomized, Controlled Trial. J Nutr. 2023 Nov;153(11):3173-3184. doi: 10.1016/j.tjnut.2023.08.011. Epub 2023 Aug 19.
Other Identifiers
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57403
Identifier Type: -
Identifier Source: org_study_id
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