The Effect of Nutritional Interventions on Exercise-induced Muscle Damage

NCT ID: NCT02839525

Last Updated: 2017-03-09

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 2 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-07-26
• Study Completion Date: 2017-02-09

Brief Summary

The study is a randomized, double-blinded, placebo-controlled trial that will include the participation of 69 women, aged 18-40 years. The aim of the study is to test nutritional strategies that help to minimize the effects of muscle damage induced by exercise.

The procedures will be performed at the Federal University of Health of Porto Alegre (UFCSPA).

Detailed Description

The exercise-induced muscle damage is associated with eccentric activities affecting muscle structural unit through micro-injury that can promote a local inflammatory response, muscle damage and delayed onset muscle soreness. These events can cause an impact on athletic performance and lower adherence to the training programs. To optimize muscle recovery after the damage caused by exercise is essential to ensure adequate caloric intake , with required amounts of macronutrients and micronutrients. Recent studies have been showed that the protein intake before sleeping is a effective strategy to inhibit muscle protein degradation, stimulate muscle protein synthesis and facilitate adaptive response of skeletal muscle to physical exercise. Furthermore, evidences on the use of anti-inflammatory nutrients have suggested that diets rich in omega 3 can reduce inflammation through inhibition of pro-inflammatory mediators. Therefore, the intake of this nutrient combined with a protein meal before sleeps and the control of food intake can improve adherence to sports training. The study will consist of three groups where everyone will receive an individualized diet. A randomization procedure will determine the type of intervention. The distribution of the groups will be as follows: group 1 (control) - volunteers follow individualized diet and olive oil capsules and maltodextrin; group 2 - intervention with omega 3 more individualized diet ; group 3 - omega 3 and whey protein isolate intervention more individualized diet.

The order of procedures to be performed will be: (1) Nutritional and Anthropometric assessment; (2) Individual orientation of diet and distribution of supplements; (3) Baseline assessment (peak torque, muscle pain levels and vastus lateralis and rectus femoris echo intensity; (4) Muscle damage induction by eccentric exercise protocol; (5) Reviews after 24h, 48h, 72h, which will follow the routine and the methods applied at baseline.

Conditions

Muscle Damage

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: DOUBLE

Study Groups

Omega 3

• 3000mg of olive oil
• Eccentric exercise: 100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Group Type: PLACEBO_COMPARATOR

Omega 3

Intervention Type: DIETARY_SUPPLEMENT

3000mg of n-3 oil (2000mg EPA e 1000mg DHA)

Eccentric exercise

Intervention Type: OTHER

100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Isolate whey protein

• 23g of maltodextrin
• Eccentric exercise: 100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Group Type: PLACEBO_COMPARATOR

Isolate whey protein

Intervention Type: DIETARY_SUPPLEMENT

23g of protein of whey protein

Eccentric exercise

Intervention Type: OTHER

100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Omega 3 and Isolate whey protein

• 3000mg of olive oil and 23g of maltodextrin
• Eccentric exercise: 100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Group Type: PLACEBO_COMPARATOR

Omega 3 and Isolate whey protein

Intervention Type: DIETARY_SUPPLEMENT

3000mg of n-3 oil (2000mg EPA e 1000mg DHA) and 23g of protein of whey protein

Eccentric exercise

Intervention Type: OTHER

100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Interventions

Omega 3

3000mg of n-3 oil (2000mg EPA e 1000mg DHA)

Intervention Type: DIETARY_SUPPLEMENT

Isolate whey protein

23g of protein of whey protein

Intervention Type: DIETARY_SUPPLEMENT

Omega 3 and Isolate whey protein

3000mg of n-3 oil (2000mg EPA e 1000mg DHA) and 23g of protein of whey protein

Intervention Type: DIETARY_SUPPLEMENT

Eccentric exercise

100 maximal eccentric contractions of knee extensors, divided into 10 sets of 10 repetitions at intervals of 60 seconds between the series

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 18 - 40 years aged
• BMI 18,5-25kg/m2
• physical exercise: < 150 minutes per week

Exclusion Criteria

• pregnancy/ lactation
• vegetarian/vegan
• chronic disease
• pulmonary and neurologic disease
• muscle injury/knee muscle injury
• medication use: anti-inflammatory and anticoagulant
• fish oil and derivate allergy
• dietary supplements use in the last month: whey protein, casein, albumin, glutamin, meat and soy protein, creatine, branched chain amino acid, high calorie supplement, n-3 supplement and antioxidants

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Federal University of Health Science of Porto Alegre

OTHER

Sponsor Role: lead

Responsible Party

Letícia Chisini Loss

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Claudia Dornelles Schneider, Doctor

Role: PRINCIPAL_INVESTIGATOR

Federal University of Health Science of Porto Alegre

Locations

UFCSPA

Porto Alegre, Rio Grande do Sul, Brazil

Countries

Brazil

Other Identifiers

51384015.5.0000.5345

Identifier Type: -

Identifier Source: org_study_id