Collagen Protein Versus Placebo on Muscle Recovery

NCT ID: NCT06465407

Last Updated: 2024-06-18

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 36 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-07-01
• Study Completion Date: 2024-12-01

Brief Summary

This study is focused on exploring the gap in the literature by comparing the effects of collagen protein versus placebo supplementation on the musculotendinous unit following muscle damaging protocol. Thus, the purpose of this study is to identify and compare the effect of collagen protein versus placebo supplementation on indirect markers of musculotendinous unit recovery following eccentric calf exercises.

Detailed Description

Various physical assessments that include pain scale, pain pressure threshold assessment, body composition, calf circumference measurements, muscle thickness measurements, Achilles tendon length and thickness measurements, myotonography of the calf, isometric force assessments during standing and seated plantarflexion positions, a heel raise test, and a standardized exercise routine focused on eccentric movements, targeting a leg chosen at random. Additionally, will consume a daily dose of two 30-g amount of collagen peptides derived from bovine hide (commercially available as Vital Proteins or Peptan) or placebo (30 g of pure maltodextrin with no amino acids) mixed in 300 ml of orange Gatorade zero.

Gatorade zero, maltodextrin, and collagen is going to be stored in the locked cabinet in the lab. Research team will mix the supplement (placebo or maltodextrin) with Gatorade zero in a non-clear bottle and will administer it to the participants on-site.

Conditions

Anthropometrics: Height and Weight; Isometric Standing and Seated Plantarflexion; Calf Muscle Thickness; Achilles Tendon Length and Thickness; Myotonography of the Calf Musculature and Achilles Tendon; Pain Pressure Threshold of the Calf; Pain Scale; Endurance Calf Test; Dietary Analysis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

Collagen

Collagen supplementation group will have 12 participants. They will perform various physical assessments that include pain scale, pain pressure threshold assessment, body composition, calf circumference measurements, muscle thickness measurements, Achilles tendon length and thickness measurements, myotonography of the calf, isometric force assessments during standing and seated plantarflexion positions, a heel raise test, and a standardized exercise routine focused on eccentric movements, targeting a leg chosen at random. Additionally, they will consume a daily dose of two 30-g amount of collagen peptides derived from bovine hide (commercially available as Vital Proteins or Peptan).

Group Type: EXPERIMENTAL

Collagen

Intervention Type: DIETARY_SUPPLEMENT

Participants will consume two 30-g amount of collagen peptides derived from bovine hide (commercially available as Vital Proteins or Peptan) mixed in 300 ml of orange gatorade zero.

Placebo

Placebo supplementation group will have 12 participants. They will perform various physical assessments that include pain scale, pain pressure threshold assessment, body composition, calf circumference measurements, muscle thickness measurements, Achilles tendon length and thickness measurements, myotonography of the calf, isometric force assessments during standing and seated plantarflexion positions, a heel raise test, and a standardized exercise routine focused on eccentric movements, targeting a leg chosen at random. Additionally, they will consume a daily dose of placebo (two 30 g of pure maltodextrin with no amino acids) mixed in 300 ml of orange Gatorade zero.

Group Type: PLACEBO_COMPARATOR

Maltodextrin

Intervention Type: DIETARY_SUPPLEMENT

Participants will consume two 30-g amount of pure maltodextrin mixed in 300 ml of orange gatorade zero.

Control

Control group (n=12) will receive no supplement. Control group participants will do all the assessments that the intervention participants are performing, except for the standardized exercise routine focused on the eccentric movements. Randomization will be performed via www.randomizer.org website.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Collagen

Participants will consume two 30-g amount of collagen peptides derived from bovine hide (commercially available as Vital Proteins or Peptan) mixed in 300 ml of orange gatorade zero.

Intervention Type: DIETARY_SUPPLEMENT

Maltodextrin

Participants will consume two 30-g amount of pure maltodextrin mixed in 300 ml of orange gatorade zero.

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Males between the ages of 18-30 years old
• Determined to be healthy by PAR-Q+ and the HHQ

Exclusion Criteria

• Untrained (no resistance training in the past 3 months)
• Allergy to bovine collagen or maltodextrin

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Central Florida

OTHER

Sponsor Role: lead

Responsible Party

Ecaterina Vasenina

Graduate Research Associate

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of Central Florida

Orlando, Florida, United States

Countries

United States

Facility Contacts

David Fukuda, PhD

Role: primary

david.fukuda@ucf.edu

Other Identifiers

UCFlorida1

Identifier Type: -

Identifier Source: org_study_id