The Effect of a Plant-blend Protein Isolate on Post-exercise Myofibrillar Protein Synthesis

NCT ID: NCT06129513

Last Updated: 2023-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-02-24

Study Completion Date

2022-10-31

Brief Summary

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Dietary protein ingestion is required to maximise the anabolic response during the recovery from resistance exercise. Whey protein is considered the optimal dietary strategy to maximise post-exercise muscle protein synthesis, but animal-protein production and consumption is associated with growing environmental and ethical concerns. Plant-based protein sources are considered of lesser anabolic quality than isonitrogenous boluses of animal-derived protein attributed to, at least in part, deficiencies in key essential amino acid. Blending different protein sources may overcome amino acid deficiencies and potentiate the post-exercise anabolic response. In the present study the investigators assessed the post-exercise muscle protein synthetic response following the ingestion of a novel plant-based protein isolate when compared with an isonitrogenous bolus of whey protein in healthy young, resistance trained women and men.

Detailed Description

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Conditions

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Muscle Metabolism

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Whey protein isolate

Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate

Group Type ACTIVE_COMPARATOR

Bilateral resistance exercise

Intervention Type BEHAVIORAL

A bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension

Whey protein

Intervention Type DIETARY_SUPPLEMENT

Following execution of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate

Plant-blend isolate

Following a bout of bilateral resistance exercise, participants will ingest 32 g protein from a novel plant-blend protein isolate

Group Type EXPERIMENTAL

Bilateral resistance exercise

Intervention Type BEHAVIORAL

A bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension

Plant-blend protein

Intervention Type DIETARY_SUPPLEMENT

Following execution of bilateral resistance exercise, participants will ingest 32 g protein from plant-blend protein isolate

Interventions

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Bilateral resistance exercise

A bout of bilateral resistance exercise consisting of barbell back squat, leg leg press and leg extension

Intervention Type BEHAVIORAL

Whey protein

Following execution of bilateral resistance exercise, participants will ingest 32 g protein from whey protein isolate

Intervention Type DIETARY_SUPPLEMENT

Plant-blend protein

Following execution of bilateral resistance exercise, participants will ingest 32 g protein from plant-blend protein isolate

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* BMI between 18 - 30
* Resistance trained (\>3 times per week structured resistance exercise training for at least 3 months)

Exclusion Criteria

* Any metabolic impairment
* Any cardiovascular impairment
* Smoking
* Lactose intolerance
* Allergies to products containing dairy, meat or nuts
* Prescribed intake of over the counter pharmaceuticals
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Exeter

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Exeter

Exeter, , United Kingdom

Site Status

Countries

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United Kingdom

References

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VAN DER Heijden I, Monteyne AJ, West S, Morton JP, Langan-Evans C, Hearris MA, Abdelrahman DR, Murton AJ, Stephens FB, Wall BT. Plant Protein Blend Ingestion Stimulates Postexercise Myofibrillar Protein Synthesis Rates Equivalently to Whey in Resistance-Trained Adults. Med Sci Sports Exerc. 2024 Aug 1;56(8):1467-1479. doi: 10.1249/MSS.0000000000003432. Epub 2024 Mar 23.

Reference Type DERIVED
PMID: 38537270 (View on PubMed)

Other Identifiers

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22-02-02-B-02

Identifier Type: -

Identifier Source: org_study_id

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