Plant Protein Blend and Milk Protein Supplements in Older Individuals
NCT ID: NCT06403137
Last Updated: 2025-12-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
51 participants
INTERVENTIONAL
2024-06-26
2025-12-05
Brief Summary
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Objective To assess the benefit of daily protein supplementation with either a plant-based protein blend or a milk protein on top of a standard diet to stimulate integrated muscle protein synthesis rates in healthy older individuals with and without exercise.
Hypotheses It is hypothesized that both the plant protein blend and the milk protein supplement will result in greater muscle protein build-up when compared with a standard diet control condition.
It is also hypothesized that exercise will result in greater muscle protein build-up when compared to the resting leg in all conditions, with similar effects of the protein supplements vs the control diet as in the non-exercised leg.
This study will show the potential benefit of protein supplementation with alternative protein sources to support skeletal muscle maintenance in older individuals.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
TRIPLE
Study Groups
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Maltodextrin
daily 2 x 20g maltodextrin ingestion
Maltodextrin supplement
Dissolved in water with breakfast and prior to sleep.
Resistance exercise
4 single-leg exercise sessions
Standardized diet
Fully standardized provided energy-balanced diet providing recommended daily allowance for protein.
Milk protein
daily 2 x 20g milk protein ingestion
Milk protein supplement
Dissolved in water with breakfast and prior to sleep.
Resistance exercise
4 single-leg exercise sessions
Standardized diet
Fully standardized provided energy-balanced diet providing recommended daily allowance for protein.
Plant protein blend
daily 2 x 20g plant protein blend ingestion
Plant protein supplement
Dissolved in water with breakfast and prior to sleep.
Resistance exercise
4 single-leg exercise sessions
Standardized diet
Fully standardized provided energy-balanced diet providing recommended daily allowance for protein.
Interventions
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Plant protein supplement
Dissolved in water with breakfast and prior to sleep.
Maltodextrin supplement
Dissolved in water with breakfast and prior to sleep.
Milk protein supplement
Dissolved in water with breakfast and prior to sleep.
Resistance exercise
4 single-leg exercise sessions
Standardized diet
Fully standardized provided energy-balanced diet providing recommended daily allowance for protein.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Aged between 60 and 80 y inclusive
* BMI between 18.5 and 30 kg/m2
Exclusion Criteria
* Intolerant to milk products
* Corn allergy
* Pea allergy
* Participating currently or in the 3 months prior to the study in a structured (progressive) exercise program.
* Smoking regularly (i.e. \>5 cigarettes/week)
* History of cardiovascular, respiratory, gastrointestinal, urogenital, neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine, haematological, immunologic disorders, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol, interfere with the execution of the experiment, or potential influence the study outcomes (to be decided by the principal investigator and responsible physician)
* Diagnosed with phenylketonuria (PKU)
* Uncontrolled hypertension (blood pressure above 160/100 mmHg)
* Donated blood 3 months prior to test day
* Use of any medications that interferes with study participation and/or outcomes (i.e. corticosteroids, non-steroidal anti-inflammatories, gastric acid suppressing medication) as assessed by the responsible medical doctor.
* Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants
* Pregnancy
60 Years
80 Years
ALL
Yes
Sponsors
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Cargill
INDUSTRY
Maastricht University Medical Center
OTHER
Responsible Party
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Principal Investigators
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Luc van Loon, PhD
Role: PRINCIPAL_INVESTIGATOR
Maastricht University
Locations
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Maastricht University Medical Center+
Maastricht, Limburg, Netherlands
Countries
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Other Identifiers
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NL85365.068.23 / METC23-050
Identifier Type: -
Identifier Source: org_study_id