The Effect of Protein Ingestion on the Recovery of Skeletal Muscle Function Following Eccentric Exercise.

NCT ID: NCT02980900

Last Updated: 2018-10-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-01

Study Completion Date

2018-08-01

Brief Summary

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The present study will assess the effect of the type and timing of protein ingestion 6 days prior to, and 7 days following eccentric exercise on the time course of 1) the recovery of muscle function, 2) the recovery of perceived muscle soreness, 3) muscle metabolism.

Detailed Description

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Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Placebo supplement

Post exercise placebo supplement Pre bed placebo supplement

Group Type PLACEBO_COMPARATOR

Post exercise placebo supplement

Intervention Type DIETARY_SUPPLEMENT

Participants will ingest an isocaloric placebo supplement after exercise. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Pre bed placebo supplement

Intervention Type DIETARY_SUPPLEMENT

Participants will ingest an isocaloric placebo supplement before bed. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Post exercise supplement

Post exercise protein-polyphenol supplement Pre bed placebo supplement

Group Type ACTIVE_COMPARATOR

Post exercise protein-polyphenol supplement

Intervention Type DIETARY_SUPPLEMENT

Participants will ingest a post exercise protein-polyphenol supplement. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Pre bed placebo supplement

Intervention Type DIETARY_SUPPLEMENT

Participants will ingest an isocaloric placebo supplement before bed. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Pre bed supplement

Post exercise placebo supplement Pre bed protein-polyphenol supplement

Group Type ACTIVE_COMPARATOR

Post exercise placebo supplement

Intervention Type DIETARY_SUPPLEMENT

Participants will ingest an isocaloric placebo supplement after exercise. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Pre bed protein-polyphenol supplement

Intervention Type DIETARY_SUPPLEMENT

Participants will ingest a protein-polyphenol supplement before bed. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Post exercise + pre bed supplement

Post exercise protein-polyphenol supplement Pre bed protein-polyphenol supplement

Group Type ACTIVE_COMPARATOR

Post exercise protein-polyphenol supplement

Intervention Type DIETARY_SUPPLEMENT

Participants will ingest a post exercise protein-polyphenol supplement. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Pre bed protein-polyphenol supplement

Intervention Type DIETARY_SUPPLEMENT

Participants will ingest a protein-polyphenol supplement before bed. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Interventions

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Post exercise protein-polyphenol supplement

Participants will ingest a post exercise protein-polyphenol supplement. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Intervention Type DIETARY_SUPPLEMENT

Post exercise placebo supplement

Participants will ingest an isocaloric placebo supplement after exercise. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Intervention Type DIETARY_SUPPLEMENT

Pre bed protein-polyphenol supplement

Participants will ingest a protein-polyphenol supplement before bed. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Intervention Type DIETARY_SUPPLEMENT

Pre bed placebo supplement

Participants will ingest an isocaloric placebo supplement before bed. This will begin 6 days before eccentric exercise and will end 6 days after eccentric exercise.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Men and women who are generally healthy and recreationally active

Exclusion Criteria

* Active cardiovascular disease or hypertension
* Diagnosed metabolic impairment
* Use of nutritional supplements
* Use of anti-inflammatory medications
* Habitual dietary protein intake of \<0.8g/kg/day
* Musculoskeletal disorders
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Exeter

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Sport and Health Sciences

Exeter, Devon, United Kingdom

Site Status

Countries

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United Kingdom

References

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Jameson TSO, Pavis GF, Dirks ML, Lee BP, Abdelrahman DR, Murton AJ, Porter C, Alamdari N, Mikus CR, Wall BT, Stephens FB. Reducing NF-kappaB Signaling Nutritionally is Associated with Expedited Recovery of Skeletal Muscle Function After Damage. J Clin Endocrinol Metab. 2021 Jun 16;106(7):2057-2076. doi: 10.1210/clinem/dgab106.

Reference Type DERIVED
PMID: 33710344 (View on PubMed)

Other Identifiers

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181739

Identifier Type: -

Identifier Source: org_study_id

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