The Effects of Protein Supplementation in Females and Males Following Acute Eccentric Exercise

NCT ID: NCT04679519

Last Updated: 2021-01-06

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 90 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-03-06
• Study Completion Date: 2019-03-25

Brief Summary

Examine the impact of the protein supplements leucine, HMB and BCAA on muscle recovery and inflammatory response following acute exercise.

Detailed Description

Participants, both females and males, will perform an acute bout of exercise. A bout of exercise that will involve multiple drop jumps. Prior to and post exercise, functional outputs will be measured and blood will be collected to quantify the inflammatory response. The protocol will involve attending the laboratory on 6 occasions over a two week period to complete the above measures.

Conditions

Muscle Damage

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Control

Control group that was not given a supplement.

Group Type: ACTIVE_COMPARATOR

Drop Jumps

Intervention Type: OTHER

Perform 100 drop jumps from 40 cm height. The protocol is divided into 5 sets of 20 repetitions. Between each repetition participants get 10 seconds, and between each set 2 minutes rest. Stand on the box, drop of the box and land with feet shoulder width apart. Then immediately bend knee to approx 45 degrees and jump straight up. Throughout each jump hands are placed on hips and should not move.

BCAA

Supplement group that was given Branched Chain Amino Acids (BCAA).

Group Type: EXPERIMENTAL

Drop Jumps

Intervention Type: OTHER

Perform 100 drop jumps from 40 cm height. The protocol is divided into 5 sets of 20 repetitions. Between each repetition participants get 10 seconds, and between each set 2 minutes rest. Stand on the box, drop of the box and land with feet shoulder width apart. Then immediately bend knee to approx 45 degrees and jump straight up. Throughout each jump hands are placed on hips and should not move.

Leucine

Supplement group that was given Leucine.

Group Type: EXPERIMENTAL

Drop Jumps

Intervention Type: OTHER

Perform 100 drop jumps from 40 cm height. The protocol is divided into 5 sets of 20 repetitions. Between each repetition participants get 10 seconds, and between each set 2 minutes rest. Stand on the box, drop of the box and land with feet shoulder width apart. Then immediately bend knee to approx 45 degrees and jump straight up. Throughout each jump hands are placed on hips and should not move.

HMB

Supplement group that was given β-Hydroxy β-methylbutyric acid (HMB)

Group Type: EXPERIMENTAL

Drop Jumps

Intervention Type: OTHER

Perform 100 drop jumps from 40 cm height. The protocol is divided into 5 sets of 20 repetitions. Between each repetition participants get 10 seconds, and between each set 2 minutes rest. Stand on the box, drop of the box and land with feet shoulder width apart. Then immediately bend knee to approx 45 degrees and jump straight up. Throughout each jump hands are placed on hips and should not move.

Interventions

Drop Jumps

Perform 100 drop jumps from 40 cm height. The protocol is divided into 5 sets of 20 repetitions. Between each repetition participants get 10 seconds, and between each set 2 minutes rest. Stand on the box, drop of the box and land with feet shoulder width apart. Then immediately bend knee to approx 45 degrees and jump straight up. Throughout each jump hands are placed on hips and should not move.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Health recreationally active males and females.

Exclusion Criteria

• Asthma sufferers
• People with kidney disease
• People partaking in lower limb strength training
• People suffering DOMS in the past 6 months
• People already taking dietary supplements, other NSAIDs, or for example aspirin, alcohol, warfarin, phenytoin, methotrexate, lithium, diuretics, cyclosporine.
• People with bone or soft tissue injury within last 12 months
• People with gastric problems
• People with hypertension
• People who have had history of heart failure
• People with liver disease
• People with connective tissue disorders
• People with Crohn's disease
• People with ulcerative colitis
• People with peripheral arterial disease
• People with cerebrovascular disease
• Elderly population
• People with allergies to NSAIDs, Omega- 3 fatty acids and BCAAs.
• People with depression
• People with bipolar disorder
• People with diabetes
• Females who are pregnant
• People who have HIV / AIDS

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Liverpool John Moores University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Liverpool John Moores University

Liverpool, Merseyside, United Kingdom

Countries

United Kingdom

References

Howatson G, Hoad M, Goodall S, Tallent J, Bell PG, French DN. Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study. J Int Soc Sports Nutr. 2012 Jul 12;9:20. doi: 10.1186/1550-2783-9-20. eCollection 2012.

Reference Type: BACKGROUND

PMID: 22569039 (View on PubMed)

Kirby TJ, Triplett NT, Haines TL, Skinner JW, Fairbrother KR, McBride JM. Effect of leucine supplementation on indices of muscle damage following drop jumps and resistance exercise. Amino Acids. 2012 May;42(5):1987-96. doi: 10.1007/s00726-011-0928-9. Epub 2011 May 12.

Reference Type: BACKGROUND

PMID: 21562819 (View on PubMed)

Other Identifiers

16/SPS/007

Identifier Type: -

Identifier Source: org_study_id