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Effect of Exercise on Muscle Proteome Signature

NCT ID: NCT03270475

Last Updated: 2021-01-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

8 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-08-28

Study Completion Date

2017-10-15

Brief Summary

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The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men

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Detailed Description

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Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.

Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Exercise

12-15 training sessions of 30 min over 4-5 weeks

Group Type EXPERIMENTAL

exercise training

Intervention Type OTHER

subjects complete 4-5 weeks of training

Interventions

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exercise training

subjects complete 4-5 weeks of training

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy
* VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD)
* Body mass index (BMI) of 19-26 kg/m2
* Normal ECG (electrocardiography)

Exclusion Criteria

* Serious adverse effects to exercise
* Chronic disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Morten Hostrup, PhD

OTHER

Sponsor Role lead

Responsible Party

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Morten Hostrup, PhD

Assistant Professor, PhD

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Department of Nutrition, Exercise and Sports

Copenhagen, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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ACE

Identifier Type: -

Identifier Source: org_study_id

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