Manipulation of Dietary Protein and the Anabolic Response

NCT ID: NCT01820975

Last Updated: 2017-03-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Study Completion Date

2017-02-01

Brief Summary

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In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.

Detailed Description

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Conditions

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Focus: Anabolic Response to Food Intake in Young Individuals Condition Relevance: Skeletal Muscle Health, Sarcopenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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High protein intake

High protein intake: large bolus of protein in teh diet the day before testing

Group Type EXPERIMENTAL

High protein intake

Intervention Type DIETARY_SUPPLEMENT

No protein intake

No protein in the diet the day before testing

Group Type PLACEBO_COMPARATOR

Placebo comparator

Intervention Type OTHER

No protein intake

Interventions

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High protein intake

Intervention Type DIETARY_SUPPLEMENT

Placebo comparator

No protein intake

Intervention Type OTHER

Other Intervention Names

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control group

Eligibility Criteria

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Inclusion Criteria

* Males
* Aged between 18-35 years
* Healthy, recreationally active
* BMI \< 30 kg/m2

Exclusion Criteria

* Smoking
* Allergies to milk proteins (whey or casein)
* Vegetarians
* Diagnosed GI tract diseases
* Female
* Arthritic conditions
* A history of neuromuscular problems
* Previous participation in amino acid tracer studies
* Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Luc JC van Loon, PhD

Role: PRINCIPAL_INVESTIGATOR

Maastricht University

References

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Gorissen SHM, Trommelen J, Kouw IWK, Holwerda AM, Pennings B, Groen BBL, Wall BT, Churchward-Venne TA, Horstman AMH, Koopman R, Burd NA, Fuchs CJ, Dirks ML, Res PT, Senden JMG, Steijns JMJM, de Groot LCPGM, Verdijk LB, van Loon LJC. Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans. J Nutr. 2020 Aug 1;150(8):2041-2050. doi: 10.1093/jn/nxaa024.

Reference Type DERIVED
PMID: 32069356 (View on PubMed)

Other Identifiers

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METC 12-3-067

Identifier Type: -

Identifier Source: org_study_id

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