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The Effect of Creatine on Muscle Loss

NCT ID: NCT01894737

Last Updated: 2015-08-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-10-31

Study Completion Date

2015-04-30

Brief Summary

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The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people.

Detailed Description

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Seven days of one-legged knee immobilisation in young subjects with creatine or Placebo supplementation. A randomly selected leg is immobilized for seven days. Muscle mass and strength will be determined and muscle biopsies will be collected before and immediately after immobilisation. A week after the cast is removed we will assess any differences in recovery between intervention groups.

Conditions

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Muscle Loss

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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immobilisation and placebo

Seven days of one-legged knee immobilisation with placebo supplementation

Group Type PLACEBO_COMPARATOR

Placebo supplementation

Intervention Type OTHER

Seven days of one-legged knee immobilisation with placebo supplementation

immobilisation and creatine

Seven days of one-legged knee immobilisation with creatine supplementation

Group Type EXPERIMENTAL

Creatine supplementation

Intervention Type OTHER

Seven days of one-legged knee immobilisation with creatine supplementation.

Interventions

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Placebo supplementation

Seven days of one-legged knee immobilisation with placebo supplementation

Intervention Type OTHER

Creatine supplementation

Seven days of one-legged knee immobilisation with creatine supplementation.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male
* Aged from 18-35 years
* 18.5 \< BMI \< 30 kg/m2

Exclusion Criteria

* (Family) history of thrombosis
* Smoking
* Recent surgery
* Performing regular resistance training more than once per week in the past year
* Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
* Current systemic use of corticosteroids, growth hormone, testosterone, immunosuppressants or insulin
* All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
* Use of anti-coagulants
* Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate)
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Luc van Loon, PhD

Role: PRINCIPAL_INVESTIGATOR

Maastricht University

Locations

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Maastricht University Medical Centre+

Maastricht, Limburg, Netherlands

Site Status

Countries

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Netherlands

References

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Backx EMP, Hangelbroek R, Snijders T, Verscheijden ML, Verdijk LB, de Groot LCPGM, van Loon LJC. Creatine Loading Does Not Preserve Muscle Mass or Strength During Leg Immobilization in Healthy, Young Males: A Randomized Controlled Trial. Sports Med. 2017 Aug;47(8):1661-1671. doi: 10.1007/s40279-016-0670-2.

Reference Type DERIVED
PMID: 28054322 (View on PubMed)

Dirks ML, Backx EM, Wall BT, Verdijk LB, van Loon LJ. May bed rest cause greater muscle loss than limb immobilization? Acta Physiol (Oxf). 2016 Sep;218(1):10-2. doi: 10.1111/apha.12699. Epub 2016 May 20. No abstract available.

Reference Type DERIVED
PMID: 27124248 (View on PubMed)

Other Identifiers

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METC 13-3-023

Identifier Type: -

Identifier Source: org_study_id