A Protein Supplementation and Exercise Strategy to Promote Muscle Protein Anabolism in Frail Elderly People
NCT ID: NCT01110369
Last Updated: 2025-04-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
62 participants
INTERVENTIONAL
2009-11-30
2011-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
QUADRUPLE
Study Groups
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Resistance exercise training and protein drink
Protein drink
Protein drink twice a day during 6 months.
Resistance exercise training
Resistance exercise training twice per week during 6 months.
Resistance exercise training and placebo drink
Resistance exercise training
Resistance exercise training twice per week during 6 months.
Placebo drink
Placebo drink twice a day during 6 months.
Interventions
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Protein drink
Protein drink twice a day during 6 months.
Resistance exercise training
Resistance exercise training twice per week during 6 months.
Placebo drink
Placebo drink twice a day during 6 months.
Eligibility Criteria
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Inclusion Criteria
* Able to understand and perform the study procedures
Exclusion Criteria
* No recent history (within 2 years) of participating in any regular resistance exercise training program (general questionnaire)
* Use of anti-coagulation medication (except of Acetyl Salicyl acid)
* Presence of coronary heart disease (ECG)
* Renal insufficiency (eGFR \<60 mL/min/1.73 m2)
* Allergic or sensitive for milk proteins
65 Years
ALL
No
Sponsors
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Top Institute Food and Nutrition
OTHER
Maastricht University Medical Center
OTHER
Wageningen University
OTHER
Responsible Party
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Lisette de Groot
Professor
Principal Investigators
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Lisette de Groot, Professor
Role: PRINCIPAL_INVESTIGATOR
Wageningen University
Locations
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Wageningen University
Wageningen, Gelderland, Netherlands
Countries
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References
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Dorhout BG, de Groot LCPGM, van Dongen EJI, Doets EL, Haveman-Nies A. Effects and contextual factors of a diet and resistance exercise intervention vary across settings: an overview of three successive ProMuscle interventions. BMC Geriatr. 2022 Mar 9;22(1):189. doi: 10.1186/s12877-021-02733-6.
van de Rest O, van der Zwaluw NL, Tieland M, Adam JJ, Hiddink GJ, van Loon LJ, de Groot LC. Effect of resistance-type exercise training with or without protein supplementation on cognitive functioning in frail and pre-frail elderly: secondary analysis of a randomized, double-blind, placebo-controlled trial. Mech Ageing Dev. 2014 Mar-Apr;136-137:85-93. doi: 10.1016/j.mad.2013.12.005. Epub 2013 Dec 27.
Tieland M, Dirks ML, van der Zwaluw N, Verdijk LB, van de Rest O, de Groot LC, van Loon LJ. Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc. 2012 Oct;13(8):713-9. doi: 10.1016/j.jamda.2012.05.020. Epub 2012 Jul 6.
Other Identifiers
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A1002-2
Identifier Type: -
Identifier Source: org_study_id
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