Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-08-05

Study Completion Date

2026-08-05

Brief Summary

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Sarcopenia describes the progressive decline of muscle mass and strength with advancing age and is associated with increased frailty and morbidity, however we do not currently have an effective treatment. Protein feeding and exercise is known to increase muscle mass, but aged muscle shows a lower response to these stimuli leading to muscle loss over time. We do know that ingesting leucine, a building block of protein, can overcome this reduced response to protein feeding and exercise leading to increased muscle mass in older people. However, we do not understand when the optimum time to ingest leucine is to maximise muscle mass after exercise in older people. In this study we will examine the effect of feeding leucine after exercise either with a meal or between meals.

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Detailed Description

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Conditions

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Muscle Protein Synthesis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Leucine supplementation between meals

Volunteers will take leucine supplements between breakfast and lunch, between lunch and dinner, and between dinner and supper.

Group Type EXPERIMENTAL

Leucine

Intervention Type DIETARY_SUPPLEMENT

Leucine is a dietary supplement that can be easily purchased over the counter at health food stores. It is an essential amino acid and is involved in stimulate muscle protein synthesis.

Leucine supplementation with meals

Volunteers will take leucine supplements with breakfast, with lunch and with dinner.

Group Type EXPERIMENTAL

Leucine

Intervention Type DIETARY_SUPPLEMENT

Leucine is a dietary supplement that can be easily purchased over the counter at health food stores. It is an essential amino acid and is involved in stimulate muscle protein synthesis.

Interventions

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Leucine

Leucine is a dietary supplement that can be easily purchased over the counter at health food stores. It is an essential amino acid and is involved in stimulate muscle protein synthesis.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* Male, 65-75 years of age
* BMI 18-28 kg/m2
* Non smoker
* Not performing regular resistance type exercise
* Participant is willing and able to give informed consent for participation in the study

Exclusion Criteria

* A BMI \<18 or \>28 kg·m-2
* Active cardiovascular disease: uncontrolled hypertension (BP \> 160/100), angina, heart failure (class III/IV), arrhythmia, right to left cardiac shunt or recent cardiac event
* Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial)
* Respiratory disease including pulmonary hypertension or chronic obstructive pulmonary disease (COPD)
* Metabolic disease: hyper and hypo parathyroidism, untreated hyper and hypothyroidism, Cushing's disease, types 1 or 2 diabetes (treated and untreated), inborn/ congenital errors of metabolism (e.g. phenylketonuria (PKU), galactosaemia)
* Active inflammatory bowel disease
* Acute infection
* Acute or chronic renal disease
* Malignancy (or history of malignancy with 5 y)
* Recent steroid treatment (within 6 mo), or hormone replacement therapy
* Coagulopathy
* Musculoskeletal or neurological disorders
* Known allergies to any of the product ingredients
* Having taken part in a research study in the last 3 months involving invasive procedures or an inconvenience allowance

Minimum Eligible Age

65 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes