Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
26 participants
INTERVENTIONAL
2017-05-12
2018-08-30
Brief Summary
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It is well established that muscle protein synthesis at the molecular level is regulated by a cellular protein complex called mTORC1. When exposed to a growth stimulus, mTORC1 has been shown to associate with lysosomes, i.e. the intracellular organelles responsible for the breakdown of cellular proteins, and subsequently moving towards the cell periphery.
This movement of lysosome-associated mTORC1 within the cell is believed to be vital for the activation of protein synthesis, as inhibition of lysosomal movement blunts mTORC1 activation in response to amino acids. Thus, dysregulation of lysosomal movement in ageing muscle may represent an underlying mechanism in the development of anabolic resistance. However, this area of research is unexplored in the context of human skeletal muscle. The investigators hypothesize that dysregulation of lysosomal movement plays a central role in the development of age-associated skeletal muscle anabolic resistance.
Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Resting leg of young males
Essential amino acids
240 mg essential amino acids per kg body weight dissolved in 500 ml of water provided after exercise.
Exercising leg of young males
Essential amino acids
240 mg essential amino acids per kg body weight dissolved in 500 ml of water provided after exercise.
Resting leg of elderly males
Essential amino acids
240 mg essential amino acids per kg body weight dissolved in 500 ml of water provided after exercise.
Exercising leg of elderly males
Essential amino acids
240 mg essential amino acids per kg body weight dissolved in 500 ml of water provided after exercise.
Interventions
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Essential amino acids
240 mg essential amino acids per kg body weight dissolved in 500 ml of water provided after exercise.
Eligibility Criteria
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Inclusion Criteria
Have a BMI (body mass index, body weight/height in m2) between 18 and 25 kg/m2, which is considered a normal body mass index.
Be in good general health: no cardiovascular diseases or metabolic diseases.
Exclusion Criteria
Generalized neuromuscular disease (such as Parkinson's disease or motorneuron disease).
Involvement in regular structured resistance exercise training at the time of the study.
Consumption of any analgesic drugs, anti-inflammatory drugs, or medication that is known to affect protein metabolism (beta-blockers, corticosteroids, NSAIDs).
Participants who have undergone muscle biopsy testing or isotope infusion procedures within the last 5 years.
Allergic to lidocaine
18 Years
75 Years
MALE
Yes
Sponsors
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University of Birmingham
OTHER
Responsible Party
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William Apro
Ph.D.
Locations
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School of Sport, Exercise and Rehabilitation Sciences at University of Birmingham
Birmingham, West Midlands, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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William Apro, Ph.D.
Role: primary
Other Identifiers
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RG_16-200
Identifier Type: -
Identifier Source: org_study_id