Combined Nutrient Intake and Muscle Protein Synthesis

NCT ID: NCT01239277

Last Updated: 2011-09-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

48 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-01-31

Study Completion Date

2011-07-31

Brief Summary

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Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether combined nutrient intake plays an important role in stimulation of the muscle protein growth in elderly people; and whether it represent effective strategies to overcome the impaired muscle protein synthesis in elderly when compared with young subjects.

Detailed Description

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Conditions

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Aging

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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protein (elderly)

Group Type EXPERIMENTAL

protein

Intervention Type OTHER

20g protein

protein and carbohydrate (elderly)

Group Type EXPERIMENTAL

protein and carbohydrate

Intervention Type OTHER

20g protein and 20g carbohydrate

protein and carbohydrate (young)

Group Type EXPERIMENTAL

protein and carbohydrate

Intervention Type OTHER

20g protein and 20g carbohydrate

protein and leucine (elderly)

Group Type EXPERIMENTAL

protein and leucine

Intervention Type OTHER

20g protein, 2.5g leucine

Interventions

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protein

20g protein

Intervention Type OTHER

protein and carbohydrate

20g protein and 20g carbohydrate

Intervention Type OTHER

protein and leucine

20g protein, 2.5g leucine

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* males
* 70-85 years or 18-30 years
* BMI \< 30

Exclusion Criteria

* Type II diabetes
* All co morbidities interacting with mobility and muscle metabolism of the lower limbs
* Use of anticoagulants
* Patients suffering from Phenylketonuria
* Participation in any regular exercise programme
Minimum Eligible Age

70 Years

Maximum Eligible Age

85 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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A. de Lange

Role: PRINCIPAL_INVESTIGATOR

Maastricht University Medical Center

Locations

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Universiteit Maastricht, Bewegingswetenschappen

Maastricht, Limburg, Netherlands

Site Status

Countries

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Netherlands

Related Links

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http://www.m3-research.nl

Information about research performed by the Maastricht Muscle Metabolism group at MUMC

Other Identifiers

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MEC 10-3-080

Identifier Type: -

Identifier Source: org_study_id

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