The Impact of Plant-based Blends on Skeletal Muscle Protein Synthesis Rates in Older Adults

NCT ID: NCT05917223

Last Updated: 2024-10-03

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 48 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-07-01
• Study Completion Date: 2025-05-31

Brief Summary

Lifestyle interventions such as physical activity and dietary habits are the most effective non-pharmacological strategies to combat the loss of muscle mass and the development of mobility limitations with aging. Resistance training (i.e., strengthening exercise) provides a strong stimulus to build muscle mass, and protein provides the essential building blocks. Therefore, an individual's dietary practices can influence the effectiveness of an exercise program - when combined, they work together to increase the muscle-building response. However, not all proteins are equally effective at bringing about muscle growth.

Therefore, the purpose of this study is to investigate the effect of a higher-quality plant-based protein blend with lifting weight on muscle building in older men and women.

Detailed Description

Dietary interventions are similarly pertinent in preventing skeletal muscle mass losses with aging. Dietary protein ingestion provides the necessary substrates (i.e., amino acids) essential for skeletal muscle development, health, and, thus, maintenance of muscle mass. Protein ingestion and resistance exercise training (RET) increase muscle protein synthesis (MPS), but when combined, they act synergistically to maximize MPS. Importantly, not all protein sources are equivalent in their ability to support increased rates of MPS. A recent study confirmed that a blend of plant proteins at a large dose of 30 g resulted in similar MPS as 30g of milk protein in young men. However, the impact of a unique plant-derived protein blend on MPS in older individuals is yet to be determined. Therefore, the purpose of this study is to address that knowledge gap by assessing the skeletal muscle anabolic potential of a plant-based protein blend (i.e., corn and pea) on rates of MPS, with or without additive exercise in older men and women.

Conditions

Nutrition, Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Milk protein ingestion

Consuming 20 g of Milk Protein dissolved in 350mL of water, one time at the experiment visit

Group Type: EXPERIMENTAL

Milk protein ingestion

Intervention Type: DIETARY_SUPPLEMENT

It's just an acute intervention, so the participant assigned to the Milk protein ingestion group will consume 20 g of milk protein during infusion protocol.

Corn protein ingestion

Consuming 20 g of Corn protein isolation dissolved in 350mL of water, one time at the experimental visit

Group Type: EXPERIMENTAL

Cron protein ingestion

Intervention Type: DIETARY_SUPPLEMENT

It's just an acute intervention, so the participant assigned to the Corn protein ingestion group will consume 20 g of corn protein isolation during infusion protocol.

Corn+Pea protein ingestion

Consuming 20 g of Corn+Pea protein isolation dissolved in 350mL of water, one time at the experimental visit

Group Type: EXPERIMENTAL

Corn+Pea protein ingestion

Intervention Type: DIETARY_SUPPLEMENT

It's just an acute intervention, so the participant assigned to the Corn+Pea protein ingestion group will consume 20 g of Corn+Pea protein isolation during infusion protocol.

Non-protein, low energy

Consuming 20 g of carbohydrate dissolved in 350mL of water, one time at the experimental visit

Group Type: EXPERIMENTAL

Non-protein, low energy

Intervention Type: DIETARY_SUPPLEMENT

It's just an acute intervention, so the participant assigned to the Non-protein, low energy group will consume 20 g of carbohydrate during infusion protocol.

Interventions

Milk protein ingestion

It's just an acute intervention, so the participant assigned to the Milk protein ingestion group will consume 20 g of milk protein during infusion protocol.

Intervention Type: DIETARY_SUPPLEMENT

Cron protein ingestion

It's just an acute intervention, so the participant assigned to the Corn protein ingestion group will consume 20 g of corn protein isolation during infusion protocol.

Intervention Type: DIETARY_SUPPLEMENT

Corn+Pea protein ingestion

It's just an acute intervention, so the participant assigned to the Corn+Pea protein ingestion group will consume 20 g of Corn+Pea protein isolation during infusion protocol.

Intervention Type: DIETARY_SUPPLEMENT

Non-protein, low energy

It's just an acute intervention, so the participant assigned to the Non-protein, low energy group will consume 20 g of carbohydrate during infusion protocol.

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• Older (60-80 y) men and women
• Be in good general health
• Non-smoking
• Recreationally active but not meet Canada's Physical Activity Guidelines (150 min of moderate-intensity exercise/week)
• Have a body mass index (BMI) between 18.5-30 kg/m2 (inclusive)
• Willing and able to provide informed consent (speaks and understands English)

Exclusion Criteria

• Use of tobacco or related products
• Use assistive walking devices (e.g., cane or walker)
• Any concurrent medical, orthopedic, or psychiatric condition that, in the opinion of the investigator, would compromise his/her ability to comply with the study requirements
• History of cancer within the last 5 years, except basal cell carcinoma, non-squamous skin carcinoma, prostate cancer or carcinoma in situ with no significant progression over the past 2 years
• Significant orthopedic, cardiovascular, pulmonary, renal, liver, infectious disease, immune disorder, metabolic/endocrine, neuromuscular or bone wasting disorders
• Any cachexia-related condition (e.g., relating to cancer, tuberculosis or human immunodeficiency virus infection and acquired immune deficiency syndrome) or any genetic muscle diseases or disorders
• History of statin myalgia
• Current illnesses which could interfere with the study (e.g., prolonged severe diarrhea, regurgitation, difficulty swallowing)
• Excessive alcohol consumption (>21 units/week)
• History of bleeding diathesis, platelet or coagulation disorders, or antiplatelet/anticoagulation therapy (up to 81mg of baby aspirin per day taken as a prophylactic is permitted).
• Routine/daily usage of non-steroidal anti-inflammatory drugs (NSAIDS, prescription use or daily use of over-the-counter medication), use of corticosteroids, testosterone replacement therapy (ingestion, injection, or transdermal), any anabolic steroid, creatine, whey protein supplements, casein or branched-chain amino acids (BCAAs) within 45 days prior to screening.
• A history of falls determined by a score >25 on the Falls Efficacy Scale-International (FES-I).

• Minimum Eligible Age: 60 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

McMaster University

OTHER

Sponsor Role: lead

Responsible Party

Stuart Phillips

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Stuart Phillips, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

Ivor Wynne Centre

Hamilton, Ontario, Canada

Countries

Canada

Other Identifiers

16408

Identifier Type: -

Identifier Source: org_study_id