Aminoacidemia and Protein Kinetics in Response to the Ingestion of Plant-based Protein Blends

NCT ID: NCT05139160

Last Updated: 2024-10-08

Basic Information

• Recruitment Status: ACTIVE_NOT_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 8 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-08-15
• Study Completion Date: 2025-07-10

Brief Summary

The present investigation aims to study a novel plant based protein isolate blend to determine if it results in similar muscle building responses compared to whey protein isolate.

Detailed Description

Whey protein is considered the 'gold standard' to maintain body proteins (muscle, skin, bone). When isolated from milk, whey protein isolate (WPI) contains all nine essential amino acids (EAA) which are 'building blocks' that are needed to support the maintenance of body proteins. To date, there is no plant-based protein (PBP) isolate that compares to the recommended WPI towards how our body builds or supports our muscles. WPI is considered the 'gold standard' because it contains all of the EAA which provide the right amount of 'building blocks' to support our muscles. Current PBP isolates available contain insufficient amounts of EAA, and are less digestible, resulting in less 'building blocks' available to support our muscles. Recently, plant protein combinations have been designed to provide the right amounts of all the EAAs. Therefore, the aim of the present study is to determine the effects of a novel PBP blend on muscle protein synthesis responses by comparing it to WPI.

Conditions

Nutrition, Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: DOUBLE

Study Groups

Whey protein isolate

Whey protein isolate is the 'gold standard' of protein supplements due to being rich in essential amino acids and leucine. Leucine is a key amino acid the is required to stimulate muscle protein synthesis. Muscle protein synthesis is the major mechanism the underpins muscle growth. The whey protein would ostensibly serve as a positive control.

Group Type: EXPERIMENTAL

Protein quality

Intervention Type: DIETARY_SUPPLEMENT

the present investigation aims to study a novel protein based protein isolate blend with and without leucine an compared with whey protein isolate to determine its impact aminoacidemia and muscle protein synthesis healthy adults.

Plant based protein isolate

Current plant-based protein isolates available contain insufficient amounts of leucine, and are less digestible, resulting in a reduced muscle protein synthesis responses. The plant based protein would ostensibly serve as a negative control.

Group Type: EXPERIMENTAL

Protein quality

Intervention Type: DIETARY_SUPPLEMENT

the present investigation aims to study a novel protein based protein isolate blend with and without leucine an compared with whey protein isolate to determine its impact aminoacidemia and muscle protein synthesis healthy adults.

Plant based protein isolate + leucine

Enriching plant-based protein with leucine will increase the 'quality' of said protein source and theoretically should have similar muscle protein synthetic responses to whey protein.

Group Type: EXPERIMENTAL

Protein quality

Intervention Type: DIETARY_SUPPLEMENT

the present investigation aims to study a novel protein based protein isolate blend with and without leucine an compared with whey protein isolate to determine its impact aminoacidemia and muscle protein synthesis healthy adults.

Interventions

Protein quality

the present investigation aims to study a novel protein based protein isolate blend with and without leucine an compared with whey protein isolate to determine its impact aminoacidemia and muscle protein synthesis healthy adults.

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

1. Male or female, between the ages of 18 - 30 years (inclusive)

2. Have a body mass index (BMI) between 18-30 kg·m2 (inclusive)

3. Be in general good health as assessed by a general health questionnaire

4. Non-smoking

5. Regular menstrual cycle and not using hormonal contraceptives

6. Willing and able to provide informed consent

Exclusion Criteria

1. Currently using analgesic or anti-inflammatory drugs

2. A history of neuromuscular problems or muscle and/or bone wasting diseases

3. Any acute or chronic illness, metabolic disorders

4. Currently using corticosteroids

5. Use of hormonal contraceptives or anabolic steroids (e.g. testosterone)

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 30 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

McMaster University

OTHER

Sponsor Role: lead

Responsible Party

Stuart Phillips

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Stuart Phillips, PhD

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

Changhyun Lim

Hamilton, Ontario, Canada

Countries

Canada

References

Lim C, Janssen TA, Currier BS, Paramanantharajah N, McKendry J, Abou Sawan S, Phillips SM. Muscle Protein Synthesis in Response to Plant-Based Protein Isolates With and Without Added Leucine Versus Whey Protein in Young Men and Women. Curr Dev Nutr. 2024 May 10;8(6):103769. doi: 10.1016/j.cdnut.2024.103769. eCollection 2024 Jun.

Reference Type: DERIVED

PMID: 38846451 (View on PubMed)

Other Identifiers

14040

Identifier Type: -

Identifier Source: org_study_id