Post-exercise Dietary Protein Strategies

NCT ID: NCT01319513

Last Updated: 2011-03-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 8 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-07-31
• Study Completion Date: 2009-10-31

Brief Summary

Protein ingestion increases the rate at which the body builds new proteins in skeletal muscle (muscle protein synthesis. This study is designed to examine how the pattern of feeding affects muscle protein synthesis following resistance exercise. There is reason to believe that the large rapid increase in blood amino acid concentrations that accompanies the ingestion of a bolus of protein is important to increasing muscle protein synthesis. Thus, we hypothesize that the consumption a bolus of protein will elevate muscle protein synthesis to a greater extent than the consumption of an equivalent amount of protein that is consumed in small divided doses.

Detailed Description

The rapid appearance into the blood of essential amino acids, and leucine in particular, may act as an important signal to stimulate muscle protein synthesis after resistance exercise. This may explain why consuming rapidly-absorbed whey protein may have an anabolic edge over slowly-absorbed proteins such as casein. Previous investigations into importance of the rate of absorption to muscle protein synthesis that have used 'fast' and 'slow' proteins have been confounded by differences in amino acid composition. The present study addresses this issue by administering the same protein source, whey, as either a bolus or in small divided 'pulse' doses to achieve divergent amino acid profiles after a bout of resistance exercise.

This study is being conducted in young (18-35) men.

Our outcome measures include: blood amino acid concentrations, rates of myofibrillar protein synthesis, anabolic intracellular signalling markers

Conditions

Optimal Anabolic Nutrition Interventions

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Blinding Strategy: NONE

Study Groups

protein feeding

Participants will complete 2 trials in a cross-over fashion in which they will consume whey protein either as a single bolus or as 10 small divided doses

Group Type: EXPERIMENTAL

whey protein bolus

Intervention Type: OTHER

single dose of 25 g whey protein

whey protein pulses

Intervention Type: OTHER

10 2.5 g pulses of whey protein

Interventions

whey protein bolus

single dose of 25 g whey protein

Intervention Type: OTHER

whey protein pulses

10 2.5 g pulses of whey protein

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Non-obese men (BMI <27) between the age of 18 and 35 yrs.

Exclusion Criteria

• Type II diabetes or other known diseases
• Use of medication
• Female
• Other ages or BMI than indicated above
• Resistance training > 3X/wk

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

RMIT University

OTHER

Sponsor Role: collaborator

Australian Institute of Sport

OTHER

Sponsor Role: collaborator

Nestec Ltd.

INDUSTRY

Sponsor Role: collaborator

McMaster University

OTHER

Sponsor Role: lead

Responsible Party

McMaster University

Principal Investigators

Stuart M Phillips, PhD

Role: PRINCIPAL_INVESTIGATOR

McMaster University

Locations

Ivor Wynne Centre A103, McMaster University

Hamilton, Ontario, Canada

Countries

Canada

References

West DW, Burd NA, Coffey VG, Baker SK, Burke LM, Hawley JA, Moore DR, Stellingwerff T, Phillips SM. Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. Am J Clin Nutr. 2011 Sep;94(3):795-803. doi: 10.3945/ajcn.111.013722. Epub 2011 Jul 27.

Reference Type: DERIVED

PMID: 21795443 (View on PubMed)

Other Identifiers

Darwin 1a - Bolus versus Pulse

Identifier Type: -

Identifier Source: org_study_id